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Cat and Dog Preventative Medicine: Breeding and Genetic Medicine

Cat and Dog Preventative Medicine: Breeding and Genetic Medicine. Dr. N. Matthew Ellinwood, D.V.M., Ph.D. April 2, 2012. Iowa State University College of Agriculture and Life Sciences. Breeding Management and Disease Prevention. Infectious Agents Genetic Disease Simple Complex.

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Cat and Dog Preventative Medicine: Breeding and Genetic Medicine

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  1. Cat and DogPreventative Medicine:Breeding and Genetic Medicine Dr. N. Matthew Ellinwood, D.V.M., Ph.D. April 2, 2012 Iowa State University College of Agriculture and Life Sciences

  2. Breeding Management andDisease Prevention • Infectious Agents • Genetic Disease • Simple • Complex

  3. Infectious Disease • Canine Agents • Feline Agents

  4. Canine Agents • Brucella canis • Cause of reproductive failure and zoonotic • Transmissible canine venereal tumor • Tumor cells are the infectious agent • Over 6000 years old • Current form is 200-2000 years old • Issue in tropics/subtropics

  5. Feline Agents • Retroviruses • FIV • FeLV

  6. Feline Blood Type Incompatibility • B queens bred to A toms or A carrier toms • Blood typing • DNA testing for B carrier status

  7. B Blood Frequency by Breed

  8. Breeds at Risk(Summary) • Exclusive A cats • Siamese • Tonkinese • Oriental Shorthair • Other breeds at risk ranging from 1% to greater than 25% (i.e. British shorthairs)

  9. Cardiac Evaluationand Thyroid Evaluation • Heart • Echo • Dipl. ACVIM (Cardio) • Thyroid • Blood tests • OFA (Orthopedic Foundation for Animals)

  10. Recessive Genetic Disease in Dogs and Cats • Dozens of genetic disease in dogs and cats for which genetic tests exist • DNA based tests are usually breed specific • Some breeds share mutations • Involve serious inherited recessive diseases of various body systems • Vision • Lysosomal Storage Diseases • Hematological Disorders

  11. Miniature Poodle Miniature Schnauzer Newfoundland Nova Scotia Duck Tolling Retrievers Papillon Pembroke Welsh Corgi Poodles (all varieties) Portuguese Water Dog Samoyeds Schipperke Scottish Terrier Shetland Sheepdog Shih Tzu Siberian Huskies Sloughis Toy Poodles West Highland White Terrier Wheaten Terrier Whippet Wire-haired Pointing Griffon Airdale Terrier American Cocker Spaniels Australian Cattle Dogs Australian Shepherd Basenji Basset Hound Bedlington Terrier Bernese Mountain Dog Briard Brittany Spaniel Bull Terrier Bullmastiffs Cairn Terrier Cardigan Welsh Corgi Chesapeake Bay Retrievers Curly-Coated Retriever Dachshunds Dalmatian Doberman Pinscher Breed Specific Tests • English Cocker Spaniels • English Pointer • English Setter • English Springer Spaniel • Field Spaniel • Flat-coated Retriever • German Short-haired Pointer • German Wire-haired Pointer • Golden Retriever • Great Dane • Greyhound • Irish Setters • Irish Red & White Setters • Kerry Blue Terrier • Labrador Retriever • Large Munsterlander • Lhasa Apso • Manchester Terrier • Mastiffs • Miniature Pinschers

  12. Commercial DNA Based Testing • Testing for diseases • Testing for traits (hair coat color) • Testing for parentage • Testing for heritage • University based, single tests • Usually developer of tests • University based, multiple tests and services • Commercial laboratories, University spin-offs • Commercial laboratories, usually little to no development • Price $75-$150 • Who you gonna call?

  13. Vet Gen Coat Color Tests • The B and b alleles of the dog • Three mutations in Tyrosinase Related Protein-1 (TRP1) involved in the chocolate coat color in “bb” Labrador retrievers (and dogs of many other breeds). • The E and e alleles of the dog • One mutation in the the Melanocortin-1 Receptor (MC1R) gene that causes the the yellow coat color in “ee” dogs.

  14. Orthopedic Evaluations • OFA • Penn Hip (1.5 years) • HD (2 years of age) • OCD • ED • Age (see above) • Retesting • Penn Hip – no • HD - yes

  15. Ocular Evaluations • CERF evaluations • ACVO • Frequency • Annually

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