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PemPlant Co.

E. P. M. PemPlant Co. April 5, 2007 Initial Prototype Presentation. Maricela Delgadillo Kay Furman Yushan Kim. Overview. Update Methylene blue staining: more results Contact angle results Mechanical force probe update Initial prototype Future characterization steps.

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PemPlant Co.

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  1. E P M PemPlant Co. April 5, 2007 Initial Prototype Presentation Maricela Delgadillo Kay Furman Yushan Kim

  2. Overview • Update • Methylene blue staining: more results • Contact angle results • Mechanical force probe update • Initial prototype • Future characterization steps

  3. Methylene Blue Staining • glass: UV vis. possible • Ti: opaque, only qualitative analysis possible.

  4. Contact Angle Measurements • Samples Tested • Bare Ti, glass, 2.0/2.0 crosslinked, 3.0/3.0 crosslinked and uncrosslinked • DI water used as Solvent • Average of three measurements

  5. Reference Data • For 3.0/3.0 system • Contact: 61 • Receding: <10 • For 2.0/2.0 system • Contact: <10 Yang, S. Y.; Mendelsohn, J. D.; Rubner, M. F. Biomacromolecules. 2003, 4 (4), 987-94

  6. Results for Glass System • Glass • Contact: 83.7º • Receding: 73º • 2.0/2.0 Crosslinked • 10.6º • 3.0/3.0 Crosslinked • 29.45º • 3.0/3.0 Uncrosslinked • 12.4º Glass 2.0/2.0 x-linked

  7. Results for Ti System 2.0/2.0 x-linked • Bare Ti • 38.3º • 2.0/2.0 Crosslinked • 31.35º • 3.0/3.0 Crosslinked • 80.2º • 3.0/3.0 Uncrosslinked • 67.4º 3.0/3.0 un x-linked

  8. Results • Bare Ti Lit review measures about 100º • Lower value may be due to surface roughness • Significant increase in contact angle measurements on Ti surfaces as compared to Glass • Polymer film on Ti results in a more hydrophobic surface • Glass system results in a more hydrophillic surface

  9. Initial Prototype • Cleaning: acetone wipe, ethanol sonication • Layers: • Polyanion (PAA) 15min, rinse 3x (2, 1, 1 min) • Polycation 15 min, rinse 3x (2, 1, 1 min)

  10. Next Characterization Steps • Mechanical Force Probe • Initial training completed • Practice data analyzed • Stability tests • Wear test • Antibacterial testing over prolonged time periods • Aqueous environment film durability • Shelf life test: Characterize our oldest films Final Prototype

  11. Mechanical Wear Test Motivation Simulate handling during implantation procedure Operating room conditions: Devices handled sterilely Potential handling by surgical nurse and physician Nitrile glove protected hands Risk of coating removal: Loss of antibacterial coating Potential for bacterial infection from: Skin exposure (wound) Air 11 PemPlant Co.

  12. Mechanical Wear Test 12 • Goal: Assess coating delamination risk from handling • Parameters: • Glove probe surface • Typical handling load • Number of cycles • Design and build testing apparatus • Standard Test Method • ASTM G99-04 • “Wear testing with a Pin-on-Disk Apparatus” PemPlant Co.

  13. Wear Test Apparatus 13 • Equipment: • Variable speed motor • Disk and pin setup • Sample stand • Gloved probe • Design under development PemPlant Co.

  14. Wear Test Data Analysis 14 • Need tool to assess coating wear • Ideal analysis method: • Quantitative • Comparative • Sensitive • Timely • Current characterization methods: • MFP (long T) • Methylene blue (less sensitive) PemPlant Co.

  15. Gantt Update • Website: http://web.mit.edu/3.042/team1_07/Website/Website/ Contains this and all previous presentations

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