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Detection of Spatial Connectivity via fMRI Data Analysis Checkpoint Presentation

Detection of Spatial Connectivity via fMRI Data Analysis Checkpoint Presentation. Emily C. Koch Ramesh M. Singa Dr. John Hart, Jr. (advisor) Computer Integrated Surgery II, 600.446 30 March 2001. Plan.

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Detection of Spatial Connectivity via fMRI Data Analysis Checkpoint Presentation

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  1. Detection of Spatial Connectivity via fMRI Data AnalysisCheckpoint Presentation Emily C. Koch Ramesh M. Singa Dr. John Hart, Jr. (advisor) Computer Integrated Surgery II, 600.446 30 March 2001

  2. Plan • Program comprehension experiments for patient interaction via computer and find compatible interface in the fMRI module and test patients with deficiencies of cognitive ability. • Map patients’ responses recorded by fMRI via cross-registration onto a neural map and localize the region of problem by identification of damaged spatial connectivities. • Compose an atlas of the spatial connectivities of proficient and deficient brain types – use as guide for alternate pathways for flow of information.

  3. Plan Components Token Tester Program Patient response Perform statistics Analysis Connectivity correlation fMRI data Cross-registration Labeled images Atlas

  4. Key dates • 6 February Initiate and coordinate idea with advisor • 26 February Complete project proposal • 1 March Reference summary presentation • 14 March Full update with advisor • 31 March Program completion • 2 April Full update with advisor • 4 April Interface implementation • 12 April Test stroke patient under MR

  5. Key dates (cont.) • 13 April Begin data processing • 16 April Analyze images with performance statistics • 19 April Test proficient patient • 20 April Begin data processing • 23 April Analyze images with performance statistics • 3 May Project final presentation • 11 May Project final report

  6. Present work to date • Development of token tester using Java and Swing – basic framework and program structure in place. • Implementation of electro-ferrous interface over hydraulic interface • Scheduled first patient for week of 9 April 2001 • Organized analysis procedures

  7. Present problems • Finding inexpensive interface implementation • Contact with advisor • More involved protocol not able to be programmed in simple implementation

  8. Exposures • Lose patients (short term exposure) • Experimental protocol produces no or minimal usable information for analysis • No correlation of spatial connectivites of similar cognitive deficient patients (long term exposure)

  9. Dependencies • Token tester program • fMRI module and appropriate interface • Deficient and proficient patients • Registration program and neural atlas • Powerful processor and abundant memory • Time • Patience

  10. Appendix: Program Properties • Four phase overview • Program data flow • Sample patient view of program

  11. Cognitive Testing Program- The Four Phase • Question • Displayed • players • (shapes) • in question • are • remembered Patient Performing Actions • Computation • is the result • valid? • -register and • compare • locations Results Compiled

  12. Admin runs program Displayed to Pt. No answer Question Right (<7sec) Wrong (>7sec) Congrats Sorry (20 x) Blank Screen Results EXIT print? Store EXIT

  13. Question Box

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