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Impact of Localized X-Irradiation on Neural Stem Cells' Astrocytic Differentiation

Study examines effect of localized X-irradiation on NSCs' differentiation into astrocytes. Immunofluorescent visualization reveals DSBs and differentiation markers. Results suggest a significant impact on cellular differentiation.

thibault-jaycob
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Impact of Localized X-Irradiation on Neural Stem Cells' Astrocytic Differentiation

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  1. A B D C 20 20 10 % Apoptotic nuclei % positive cells 10 ** 0 0 PM DM PM/IR PM DM PM/IR Effect of localized X-irradiation on astrocytic differentiation of NSCs. A, Immunofluorescent detection of DSBs visualized 53BP1 foci (red). White circle indicates the targeted area. B, Higher magnification picture indicates localized DSBs within the targeted area. The nuclei are counter stained with DAPI (Blue). C, Astrocytic differentiation of NSCs determined by anti-GFAP antibody. D, Neural differentiation of NSCs determined by anti-b-III tubulin antibody. IR; localized X-irradiation. The data represent the mean ± SEM. **p < 0.01. Bar indicates 50 µm. Figure S5

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