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Pathogenesis of IBD, and the Role of Biologic Therapies

Explore the events leading to intestinal inflammation in IBD, the etiologic theories, and the genetics involved. Discover the efficacy, safety concerns, and adverse events associated with biologic therapies. Learn about the evidence for combination therapy and factors driving the loss of response to monoclonal anti-TNF antibodies.

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Pathogenesis of IBD, and the Role of Biologic Therapies

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  1. Pathogenesis of IBD, and the Role of Biologic Therapies

  2. Learning Objectives

  3. Events Culminating in Intestinal Inflammation

  4. Etiologic Theories in IBD

  5. Genetics of IBD163 Confirmed Loci

  6. Anti-integrins

  7. Therapeutic Concentrations

  8. Factors that Influence Pharmacokinetics of TNF Antagonists

  9. Anti-TNF Effectiveness in CD and UC

  10. Safety Concerns With Anti-TNF Therapy

  11. Adverse Events With Vedolizumab

  12. All Biologics

  13. Biologics and Immunomodulators in Pivotal Trials

  14. Evidence for Combination Therapy in IBD in Immunosuppressive-naive Patients

  15. TREAT UpdateMultivariate Logistic Regression Analyses

  16. What Drives Loss of Response to Monoclonal Anti-TNF Antibodies?

  17. Algorithm for Loss of Response to Anti-TNF

  18. Summary

  19. Abbreviations

  20. Abbreviations (cont)

  21. References

  22. References (cont)

  23. References (cont)

  24. References (cont)

  25. References (cont)

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