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Vesicular Traffic II

Vesicular Traffic II. Endocytic and secretory pathways. red = secretory green = endocytic blue = recycling. Different coats are used for different transport steps in the cell. Assembly and disassembly of clathrin coat. Dynamin pinches clathrin coated vesicles from the membrane.

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Vesicular Traffic II

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  1. Vesicular Traffic II

  2. Endocytic and secretory pathways red = secretory green = endocytic blue = recycling

  3. Different coats are used for different transport steps in the cell

  4. Assembly and disassembly of clathrin coat

  5. Dynamin pinches clathrin coated vesicles from the membrane

  6. Electron micrograph from Drosophila mutant

  7. Resting Chemical Synapse

  8. Drosophila mutant can not recycle synaptic vesicles

  9. SNARE proteins guide vesicular transport

  10. Active Chemical Synapse

  11. Interaction of SNARE proteins while docking synaptic vesicle at nerve terminal

  12. Model for membrane fusion. Tight SNARE pairing forces water molecules from area between lipid bilayers

  13. Entry of HIV into lymphocytes

  14. Recruitment of cargo molecules into ER transport vesicles

  15. Vesicular tubular clusters move along microtubules to carry proteins from ER to Golgi apparatus

  16. Vesicular tubular clusters

  17. Microtubules

  18. Microtubules

  19. DVD Clip 58

  20. 3-dimensional model of the Golgi Apparatus

  21. Golgi apparatus in an algal cell

  22. ER – Golgi transitional zone in an animal cell

  23. Some enzymes are enriched in cis or trans compartments of the Golgi substrates specific for certain enzymes such as acid phosphatase

  24. Functional Compartmentalization of the Golgi Apparatus

  25. Golgi apparatus stained with GFP

  26. Golgi apparatus can be polarly distributedIn this fibroblast Golgi is facing the direction in which the cell is crawling

  27. Drawing of goblet cell in the intestinal epithelium Secretes polysaccharide rich mucus into the small intestine Golgi is highly polarized to facilitate release of mucus through exocytosis at the apical domain

  28. N-linked glycosylation because sugar is added to N of asparagine. original precursor oligosaccharide added to most proteins in the ER

  29. Oligosaccharide chains are processed in the Golgi complex common core high-mannose

  30. Vesicular transport model

  31. Cisternal Maturation Model

  32. Lysosome interior is different from cytosol

  33. Detection of acid phosphatase in lysosomesSmall spheres may be vesicles delivering the enzyme from the Golgi Apparatus

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