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Basket Centrifuge (BCF-101) in the Insulin Production Process

Basket Centrifuge (BCF-101) in the Insulin Production Process. Alexander Lai, Dominic Watson & Karthik Rajendiran . Location in the process. Purpose of this step. Removal of undesired chemicals Ammonium Acetate, Acetic Acid and Zinc Chloride Dewatering $$ Savings in Freeze Drying Stage.

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Basket Centrifuge (BCF-101) in the Insulin Production Process

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  1. Basket Centrifuge (BCF-101) in the Insulin Production Process Alexander Lai, Dominic Watson & Karthik Rajendiran

  2. Location in the process

  3. Purpose of this step • Removal of undesired chemicals • Ammonium Acetate, Acetic Acid and Zinc Chloride • Dewatering • $$ Savings in Freeze Drying Stage

  4. Alternatives? • Cyclone Separator (Hydroclone) • Tubular Bowl Centrifuge

  5. Schematic of Perforated Basket Centrifuge with Automatic Discharge

  6. Performance Metrics • Capacity / Max Throughput (L/min) • Solids Recovery (%) • Protein Yield (%) Photo: NASA Photo: Novo Nordisk Photo: Gregory Smutzer

  7. Process Parameters • RPM • Temperature • Feed Rate • Solids Concentration in Feed

  8. Essence of Centrifuge Design Efficiency Capital Cost Utilities Use Throughput Downtime

  9. Centrifuge Design Basis: Batch Cake Volume = 12.78 m3 • Pressure  P = Pa + 0.5L2(R2 – R2p) • G- Force  G = n2aΩ2R

  10. Materials of Construction • 5 materials were investigated • Carbon Steel • Stainless Steel • Rubber lined Steel • Bronze • Monel

  11. Cost • Area = 0.738m2 • Unfactored cost = $55,000 • M&S 2007 Index, Location and Material Factored cost = $146,000

  12. Mitsubishi HZ70L-Si

  13. Questions??

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