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Typhoid Fever. Vincent Klokman. Classic Symptoms Slow, Progressive Fever Profuse sweating Gastroenteritis. Centers for Disease Control Public Heath Image Library. Typhoid Fever is caused By the Bacterium Salmonella typhi.
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Typhoid Fever Vincent Klokman
Classic Symptoms • Slow, Progressive Fever • Profuse sweating • Gastroenteritis Centers for Disease Control Public Heath Image Library
Salmonella typhi is a motile, gram-negative facultative anaerobe.
Asymptomatic Carriage Can Spread Typhoid Fever to Many People
Salmonella Virulence due to: • Invasiveness • Intracellular survival & multiplication • Endotoxin • Cytotoxins FoodPoisonJournal.com Cred. Drew Falkenstein
Siderophores Virulence Factors and Toxins Enterotoxin (diarrhea) Type 1 fimbriae (adherence) Endotoxin in LPS layer (fever) Virulence plasmid Cytotoxin Vi capsule antigen H antigen Brock: Figure 28.17 O antigen
World Distribution of Typhoid Fever is largely in Developing Nations WHO
With prompt antibiotic therapy, more than 99% of the people with typhoid fever are cured.
Virulence plasmid Vi capsule antigen; Inhibits complement binding Brock: Figure 28.17
The Typhoid Vaccine is not Very Effective Klugman, K. "Protective Activity Of ViCapsularPolysaccharide Vaccine AgainstTyphoid Fever." The Lancet 330.8569 (1987): 1165-169. Print.
and hand reduce several Typhoid Fever Simple Hygiene Washing can Instances of
References • A.D.A.M. Medical Encyclopedia [Internet]. Atlanta (GA): A.D.A.M., Inc.; c1997-2012. Typhoid Fever; [last reviewed 2011 Jun 9; cited 2012 Mar 6]. Available from: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002308/ • Brock Biology of Microorganisms. San Francisco (Calif.): Pearson Benjamin Cummings, 2009. Print. • Klugman, K. "Protective Activity Of ViCapsularPolysaccharide Vaccine AgainstTyphoid Fever." The Lancet 330.8569 (1987): 1165-169. Print. • Merck Manual • Taber’s Medical Encyclopedia • CDC • WHO • Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261.