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Lenograstim Chemical Formula : C840-H1330-N222-O242-S8

Granocyte (Lenograstim) is a recombinant granulocyte colony-stimulating factor used to reduce infection risk in neutropenic patients, aid in hematopoietic recovery post-chemotherapy, and treat severe chronic neutropenia.

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Lenograstim Chemical Formula : C840-H1330-N222-O242-S8

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  1. LenograstimChemical Formula : C840-H1330-N222-O242-S8

  2. Description: Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immuno stimulator.

  3. Indication : The drug is used to reduce the risk of life-threatening infection in patients with neutropenia, particularly after cytotoxic chemotherapy. GRANOCYTE ( Lenograstim) is indicated as a treatment to reduce the duration of neutropenia and the severity of infections in patients with non-myeloid malignancy who have undergone autologous or allogeneic bone marrow transplantation, or treatment with established cytotoxic chemotherapy and in addition to reduce the incidence of infection associated with established cytotoxic chemotherapy. GRANOCYTE is also indicated to mobilise peripheral blood progenitor cells (PBPCs) with GRANOCYTE alone, or after myelosuppressive chemotherapy, in order to accelerate haematopoietic recovery by infusion of such cells, after myelosuppressive or myeloablative therapy. GRANOCYTE is also indicated to accelerate the engraftment of these cells after their reinfusion. GRANOCYTE is also indicated for the treatment of severe chronic neutropenia including congenital agranulocytosis (Kostmann's syndrome).

  4. Mechanism of Action : Lenograstim is the glycosylated recombinant form of human granulocyte colony stimulating factor. Lenograstim accelerates neutrophil recovery significantly after chemotherapy, with beneficial effects on clinical end-points such as incidence of laboratory-confirmed infection and length of hospital stay. Chemotherapy dose intensity has also been increased in patients receiving lenograstim, notably those with breast or small cell lung cancer, although improvements in tumour response and survival have not been demonstrated. Lenograstim also assists neutrophil recovery in patients undergoing bone marrow transplantation, and stimulates the production of peripheral blood stem cells (PBSCs) for autologous transfusion after aggressive chemotherapy. Categories : Antineoplastic and Immunomodulating Agents

  5. Brands: Granocyte Description : Granocyte injection contains the active ingredient lenograstim, which is a type of medicine called a recombinant human granulocyte-colony stimulating factor (G-CSF).

  6. Route of administration : Subcutaneous or Intravenous Contraindications:People with malignancies affecting myeloid cell. Side Effects: Decrease in the number of platelets in the blood (thrombocytopenia), Headache, Feeling weak, Bone pain, Back pain, Elevated levels of liver enzymes.

  7. References :http://www.netdoctor.co.uk/medicines/cancer/a6818/granocyte-lenograstim/https://www.drugs.com/international/lenograstim.html

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