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environmental toxins, diabe tes and obe sity . Is there a sweet Fix?

Learn about the emerging risk factors of environmental toxins on obesity and diabetes, and explore alternative treatments for weight loss and type 2 diabetes. Discover the impact of toxins on insulin resistance and weight gain, as well as the current epidemic of diabesity affecting over a billion people globally. Delve into the link between environmental toxins and obesity, as well as the alarming rise in rates of type 2 diabetes among youth. Uncover the connection between exposure to industrial pollutants and health disorders, with a focus on how heavy metals like arsenic and mercury contribute to diabetes risk.

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environmental toxins, diabe tes and obe sity . Is there a sweet Fix?

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  1. environmental toxins, diabetes and obesity. Is there a sweet Fix? withDr. Derek Lee, Direct Energy’s Health and Wellness Doctor for North America. Diabesity:

  2. Outline • work of Dr. Mark A. Hyman on environmental toxins, obesity and diabetes: emerging risk factors • toxins -> obesity -> diabetes • Carbs worse than table sugar: • high fructose corn syrup • wheat - amyelopectin A • alternative treatments for weight loss and diabetes 2

  3. Dr. Mark A. Hyman on environmental toxins, obesity and diabetes: emerging risk factors • calls the epidemic of diabetes and obesity as ‘diabesity’ • toxins are an invisible, unappreciated cause of obesity and diabetes • Exposure to environmental toxins in the absence of increased caloric intake induces weight gain and insulin resistance

  4. Numbers • From 1983 to 2008, the number of people in the world with diabetes increased seven-fold, from 35 million to 240 million • Diabesity is our modern plague. The many conditions that exist under the umbrella of diabesity affect more than one billion people worldwide 4

  5. Obesity Trends

  6. No Data <14.0% 14.0-17.9% 18.0-21.9% 22.0-25.9% >26.0% No Data <4.5% 4.5-5.9% 6.0-7.4% 7.5-8.9% >9.0% 2009 2009 2000 2000 1994 1994 Age-adjusted Percentage of U.S. Adults Who Were Obese or Who Had Diagnosed Diabetes Obesity (BMI ≥30 kg/m2) Diabetes CDC’s Division of Diabetes Translation. National Diabetes Surveillance System available at http://www.cdc.gov/diabetes/statistics

  7. Rate of new cases of type 1 and type 2 diabetes among youth aged <20 years, by race/ethnicity, 2002–2005 <10 years 10–19 years Source: SEARCH for Diabetes in Youth Study NHW=non-Hispanic whites; NHB=non-Hispanic blacks; H=Hispanics; API=Asians/Pacific Islanders; AI=American Indians

  8. First time in 200 years that the life expectancy of our children (born in 2000) is less than that of the parents

  9. Adult onset type 2 diabetes has be re-defined as just “type 2”: children as young as 8 yrs now have type 2

  10. obesity in babies • rates of obesity in infants less than 6 months old have risen 73% since 1980. • This epidemic of obesity in 6-month-olds is not related to diet or lack of exercise • Babies live on breast milk or formula and love • Babies don’t eat McDonald’s So what is the cause? Kim J, Peterson KE, Scanlon KS, et al. Trends in overweight from 1980 through 2001 among preschool-aged children enrolled in a health maintenance organization. Obesity (Silver Spring). 2006;14(7):1107-111

  11. Mounting evidence points to a unique and unappreciated trigger for obesity—exposure to small traces of environmental chemicals in the environment • The average newborn has 287 chemicals in the umbilical cord blood, 217 of which are neurotoxins • The chemicals these infants are exposed to include pesticides, phthalates, bisphenol A, flame retardants, and heavy metals such as mercury, lead, and arsenic • They are neurotoxic, carcinogenic, and now it seems, obesogenic Environmental Working Group. Study finds industrial pollution begins in the womb. Available at: http://www.ewg.org/reports/bodyburden2/newsrelease.php. Accessed January 12, 2010

  12. More Studies • A 2008 study in JAMA found that bisphenol A, a petrochemical that lines water bottles and canned food containers, increases the risk of diabetes, heart disease, and abnormal liver function • National Health and Nutrition Examination Survey 1999-2002 found a very striking correlation between blood levels of six common persistent organic pollutants (petrochemical toxins) and diabetes • Studies of Air Force veterans of the Vietnam War found that those who had been exposed to Agent Orange (dioxin) had a much higher risk for diabetes • The evidence mounts monthly... • Lang IA, Galloway TS, Scarlett A, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults . J AMA. 2008;300(11):1303-1310 • Lee DH, Lee IK, Song K, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006;29(7):1638-164 • Fujiyoshi PT, Michalek JE, Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. Environ Health Perspect. 2006;114(11):1677-83

  13. Heavy Metals • A recent article in JAMA linked arsenic exposure to increases in the risk of type 2 diabetes • Other data link mercury from fish consumption, dental amalgams, and vaccines through multiple mechanisms including enzymatic disruption, impaired glucose transport, oxidative stress, induction of inflammatory cytokines, and mitochondrial injury. Windham B. Diabetes: The Mercury and Vaccine Factor. Scientific Research Collated and Summarized. Tallahassee, FL: Dental Amalgam Mercury Syndrome, Inc; 2008 13

  14. New Studies Confirm Link Between Environmental Toxins and Obesity • In a recent study, rats given toxic chemicals gained weight and increased their fat storage without increased caloric intake or decreased exercise • In 6 months, these rats were 20% heavier and had 36% more body fat than rats that had not been exposed to those chemicals. Chen JQ, Brown TR, Russo J. Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors. Biochim Biophys Acta. 2009;1793(7):1128-1143. 14

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  16. Our genes are the same but over the last 4 generations, changes to food quality and environmental toxins have led to chronic diseases like obesity and diabetes. • mice were bred to be blond, obese and diabetic - short life expectancy • when pregnant, mice were fed methylation supplements like B12, folic acid • offspring were lean, and healthy with a normal life-span 18

  17. Supplements to Enhance Detoxification

  18. Substances that activate Phase I detoxification • Drugs: alcohol; nicotine in cigarette smoke; Phenobarbital; sulfonamides; steroids • Foods: cabbage, broccoli, and brussels sprouts; charcoal-broiled meats; high-protein diet; oranges and tangerines (but not grapefruits) • Nutrients: niacin; vitamin B1; vitamin C • Herbs: caraway and dill seeds • Environmental toxins: carbon tetrachloride; exhaust fumes; paint fumes; dioxin; pesticide 20

  19. Nutrients needed by phase II detoxification enzymes • Glutathione conjugation: Glutathione Precursors (Cysteine, Glycine, Glutamic Acid, and co-factors), Essential Fatty Acids (Black Currant Seed Oil, Flax Seed Oil, EPA), Parathyroid Tissue • Amino acid conjugation: Glycine • Methylation: Methionine, Co-factors (Magnesium, Folic Acid, B-12, Methyl Donors) • Sulfation: Molybdenum, Cysteine and precursor (Methionine), Co-factors • (B-12, Folic Acid, Methyl Donors, Magnesium, B-6/P-5-P), MSM • Acetylation: Acetyl-CoA, Molybdenum, Iron, Niacinamide, B-2 • Glucuronidation: Glucuronic acid, Magnesium • Glycination: Arginase Enzyme, Glycine, Gly Co-factors (Folic Acid, • Manganese, B-2, B-6/P-5-P 21

  20. Best Foods To Support Detox • cruciferous vegetables (cabbage, broccoli, collards, kale, Brussels sprouts, Chinese cabbage, bok choy, arugula, radish, wasabi, watercress, kohlrabi, mustard greens, rutabaga, and turnips), • curcuminoids (turmeric and curry), • green tea (increases glutathione-S-transferases), and • sulfur-containing proteins and foods (eggs, garlic, and onions) 22

  21. Best Supplements To Support Detox • most critical endogenous molecule for detoxification is glutathione • Optimal methylation is required to generate glutathione through the methylation/transsulfuration cycle, making B6, folic acid, and B12 essential • Zinc and selenium also facilitate detoxification • N-acetyl-cysteine increases glutathione and historically has • been used to treat depleted glutathione and liver failure from acetaminophen overdose • Milk thistle has long been used in liver disease and increases glutathione • Buffered ascorbic acid (vitamin C) is also critical in detoxification and has been associated with a reduction in lead level 23

  22. HYPERTHERMIC THERAPY (SAUNAS) • Sauna and heat therapies are an ancient method of cleansing • The Native American sweat lodge was a tool for physical and spiritual purification • The Environmental Protection Agency has shown that sauna therapy increases excretion of heavy metals (lead; mercury; cadmium; and fat-soluble chemicals such as PCBs, PBBs, and HCBs Cecchini M, LoPresti V. Drug residues stored in the body following cessation of use: impacts on neuroendocrine balance and behavior—use of the Hubbard sauna regimen to remove toxins and restore health. Med Hypotheses. 2007;68(4):868-879

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  24. Questions? • Contact Dr. Derek Lee at drlee@betterhealthproviders.com

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