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UMCCTS Mentors

UMCCTS Mentors. Schahram Akbarian, MD, PhD Associate Professor of Psychiatry Director-Brudnick Neuropsychiatric Research Institute I nternationally recognized on the molecular pathology of schizophrenia & other neurodevelop- mental disorders

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UMCCTS Mentors

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  1. UMCCTS Mentors

  2. Schahram Akbarian, MD, PhD • Associate Professor of Psychiatry • Director-Brudnick Neuropsychiatric Research Institute • Internationally recognized on the molecular • pathology of schizophrenia & other neurodevelop- • mental disorders • NIH funded since 2000, studying epigenetic • mechanisms in the pathophysiology of depression, • psychosis & Rett syndrome • 1997 NIMH Outstanding Resident Award • 2008 NARSAD Staglin Family Schizophrenia • Research Award • Mentored more than 10 instructors & assistant • professors, post-doc fellows & graduate students • http://www.umassmed.edu/igp/faculty/akbarian.cfm

  3. Jeroan Allison, MD, MS • Professor & Vice Chair, Quantitative Health Sciences, • Associate Vice Provost for Health Disparities • Research focuses on quality measurement, implementation science, and statistical methods, emphasis on eliminating racial/ethnic disparities • 10-year history of sustained extramural funding , including the NIH, AHCQR, RWJ Foundation • Co-Editor-in-Chief of Medical Care, sponsored by American Public Health Association • Jeroan.Allison@umassmed.edu

  4. Dario Altieri, MD • Professor of Cancer Biology • Chair-Department of Cancer Biology • Internationally recognized for work on cell • death regulation and survival in human • diseases, including cancer & acute vascular injury • Led development and preclinical characterization • of apoptosis modifiers now in clinical trials • NIH funded since 1989; MERIT award from • Heart, Lung and Blood Institutes • Mentored more than 25 pre- and post-doc • fellows http://www.umassmed.edu/cancerbiology/faculty/Altieri.cfm

  5. Victor Ambros, PhD • 2008 Lasker Prize for Basic Medical Research • Silverman Chair in Natural Sciences • Professor of Molecular Medicine • Developmental geneticist using the nematode Caenorhabditiselegans to study genetic regulatory mechanisms that control animal development • Major focus on microRNAs function in gene • regulatory networks • NIH funded for more than 20 years • 2008 Gairdner International Award; Benjamin • Franklin Medal in Life Sciences • National Academy of Sciences Member • Mentored more than 20 students & post-docs • http://www.umassmed.edu/faculty/show.cfm?faculty=1266

  6. Elliot Androphy, MD • Professor and Vice Chair of Medicine • Director-Medical Scientist Program • Internationally recognized expert on the molecular • biology of human papillomaviruses, studying novel • drug-like compounds to inhibit a key viral protein • & can be used to treat HPV induced malignancies • NCI funded to develop drug for cervical cancer • Also internationally known expert in the patho- • genesis of spinal muscular atrophy (SMA) • NIH funded through NICHD & the Chemical • Genomics Center NIMH Roadmap grant • Mentored more than 30 post-doc fellows, graduate • & medical students • http://www.umassmed.edu/faculty/show.cfm?faculty=292

  7. Neil Aronin, MD • Professor of Medicine and Cell Biology • Chief-Division of Endocrinology and Metabolism • Internationally recognized expert on the • pathogenesis of Huntington’s disease • Directs the Neuroendocrinology Laboratory • Basic research focuses on gene silencing for • autosomal dominant, neurodegenerative disease • Clinical research examines human growth • hormone in patients with hypopituitarism & • genetics of familial & sporadic pheochromocytoma • NIH or NSF funded since 1979 • Mentors MD/PhD & PhD students & sponsors • post-doc fellows for NIH & HHMI • http://www.umassmed.edu/faculty/show.cfm?faculty=263

  8. Leslie Berg, PhD • Professor of Pathology • Chair-Immunology & Virology Program • Internationally recognized expert on lymphocyte signaling, investigating the functions of key tyrosine kinases required for T cell activation & • the generation of a productive immune response to infections • NIH funded to study signaling proteins in mouse models of immunity • Chair of the Board of Scientific Counselors for • the National Institute on Aging • Mentored over 30 graduate students & post-docs • http://www.umassmed.edu/igp/faculty/berg.cfm

  9. Silvia Corvera, MD • Professor of Molecular Medicine • The Corvera lab studies the cellular & molecular • basis of energy metabolism • NIH funded studies elucidate factors controlling • angiogenesis in human adipose tissue • Bariatric surgery studies are performed in tight • coordination & collaboration with surgeons & • endocrinologists & closely involve residents, • mentored in the basic aspects of the research • Mentored more than 10 students & post-doc • fellows in the past 5 years • http://www.umassmed.edu/faculty/show.cfm?faculty=267

  10. Michael Czech, PhD • Professor of Molecular Medicine • Founding Chair-Program in Molecular Medicine • Recognized for major contributions to diabetes • research and adipocyte biology • NIH MERIT award; 2000 Banting Medal of the • American Diabetes Association • Czech laboratory focuses on the underlying • mechanisms of insulin signaling & the molecular • basis of insulin resistance in obesity & type 2 • diabetes • NIH funded for more than 25 years • Mentoreddozens of graduate students & post- • doc fellows • http://www.umassmed.edu/igp/faculty/czech.cfm

  11. Roger Davis, MA MPhil, PhD, FRS • Howard Hughes Medical Institute Investigator • H. Arthur Smith Chair & Professor of Molecular Medicine • Internationally recognized expert in signal • transduction mechanisms related to the stress • response • NIH-funded • Research on cancer, diabetes, inflammation, & • stroke has helped identify new molecular targets • Elected to The Royal Society (London) in 2002 • Editor-in-Chief, Molecular & Cellular Biology • Mentored many trainees; now successful faculty • at other Medical Schools http://www.umassmed.edu/faculty/show.cfm?faculty=181

  12. Kate Fitzgerald, PhD • Associate Professor of Medicine • Internationally recognized expert on innate • immunity and host defense with a particular focus • in pattern recognition receptors (Toll-Like • Receptors, RIG-Like Receptors, NOD-Like • Receptors) and their associated signaling pathways • Recipient of several Young Investigator awards • NIH funded since 2004 • Actively involved in the Immunology & Virology • Program • Mentored post-doc fellows, graduate & medical • Students • http://www.umassmed.edu/faculty/show.cfm?faculty=729

  13. Terence Flotte, MD • Dean, Provost, Executive Deputy Chancellor • Professor of Pediatrics • Internationally recognized as a pioneer in human • gene therapy, currently investigating its use for • pediatric genetic diseases, mainly Cystic Fibrosis • First to use adeno-associated virus (AAV) to • deliver corrective genes to targeted sites in the • body, including the damaged airways of adults • with CF, paving the way for new viral vectors for • CF gene therapy, currently undergoing pre-clinical • testing & soon to be tested in patients • Mentored more than 20 individuals http://www.umassmed.edu/faculty/show.cfm?faculty=1255

  14. Patricia Franklin, MD MBA MPH • Associate Professor of Orthopedics & Physical Rehabilitation • Director-Musculoskeletal Clinical & • Outcomes Research • Expert in clinical and outcome data analysis • NIAMS-funded research on intervention to • Enhance TKR patient adherence during rehab • RWJF-fundedeHealth research includes a • multi-site trial testing the efficacy of emails on • diet & physical activity change & development • of web-based outcome prediction tools • Supervises orthopedic clinical research of • residents (MD) & pre- & post-doc trainees http://www.umassmed.edu/faculty/show.cfm?faculty=837

  15. Robert Goldberg, PhD • Professor of Medicine and Epidemiology • Director-Master of Science in Clinical Investigation • Internationally recognized for research in cardiovascular epidemiology & preventive cardiology • NIH funded for 25 years; current MERIT awardee • Recent NIH funding for two large scale • epidemiologic studies, one to understand care • seeking in patients with acute heart failure, the • other studying venous thromboembolic disease • Senior Epidemiologist for the GRACE (Global • Registry of Acute Coronary Events) • Mentored more than 50 post-doc fellows, • medical & graduate students http://www.umassmed.edu/faculty/show.cfm?faculty=1260

  16. Douglas Golenbock, MD • Professor of Medicine, Molecular Genetics • & Microbiology • Chief-Division of Infectious Diseases • Internationally recognized expert on the innate • immune system, particularly in the recognition & • response to microbial products • Recent work includes collaboration with Brazilian • investigators on patient studies in the patho- • Genesis of P. falciparum malaria • NIH funded since 1987; currently an NIH MERIT • awardee from NIGMS • Mentored more than 40 post-doc fellows, • graduate & medical students, & ID fellows http://www.umassmed.edu/faculty/show.cfm?faculty=382

  17. Ellen Gravallese, MD • Professor of Medicine & Cell Biology • Chief-Division of Rheumatology • Internationally recognized expert on pathogenesis • of rheumatoid arthritis (RA), with recent emphasis • on the destruction of joint bone & cartilage • Lab uses animal models of RA & patient tissue • samples to understand pathogenic mechanisms of disease & identify novel treatment pathways • Harvard Medical School Scholars in Medicine Award • NIH and Arthritis Foundation funded • Mentored 14 post-doc fellows, graduate & medical students, & rheumatology fellows http://www.umassmed.edu/faculty/show.cfm?faculty=1248

  18. Michael Green, MD, PhD • Professor of Molecular Medicine • Howard Hughes Medical Institute Investigator • Director-Program in Gene Function & Expression • Internationally recognized expert in eukaryotic • gene regulation & its role in human cancers • Uses molecular biology, molecular genetics, • biochemical & RNA interference technology to • perform genome-wide screens to identify new • genes & pathways & address questions in cancer • molecular biology • NIH funded since 1984 • Mentored more than 90 post-doc fellows, • graduate & MD/PhD students http://www.umassmed.edu/faculty/show.cfm?faculty=189

  19. Jerry Gurwitz, MD • Dr. John Meyers Professor in Primary Care Medicine • Executive Director- Meyers Primary Care Institute • Chief-Division of Geriatric Medicine • Recognized for expertise in optimal drug therapy in the elderly & improving medication safety • Agency for Healthcare Research & Quality funded; NHLB-funded HMO Cardiovascular Research Network • William B. Abrams Award in Geriatric Clinical Pharmacology; George F. Archambault Award; • John M. Eisenberg Patient Safety and Quality Award • Mentored over 25 trainees http://www.umassmed.edu/faculty/show.cfm?faculty=649

  20. Thomas K. Houston, MD, MP • Director, Division of Health Informatics & Implementation Science • Leader in health informatics & technologically-based, patient-centered interventions to improve clinical care • Funded through NIH & VA • Co-chair, Behavioral Informatics Group, Society of Behavioral Medicine • Chair, Consumer Health Informatics working group, American Medical Informatics Assoc • Editorial board, Journal of Medical Internet Research • Thomas.Houston@umassmed.edu

  21. ShaleshKaushal, MD, PhD • Associate Professor of Ophthalmology • Chair-Department of Ophthalmology • Expert in vitreoretinal disorders & first in the world • to use complement inhibitor molecules to treat • patients for wet age-related macular degeneration • Current research uses gene therapy to treat a • congenital blindness known as Leber Congenital Amaurosis • Basic research targets the biochemical basis of • retinal & macular degeneration, including small • molecule drug discovery & the molecular & cellular • fate of misfolded proteins associated with retinal degeneration Shalesh.Kaushal@umassmemorial.org

  22. Catarina Kiefe, PhD, MD • Chair, Quantitative Health Sciences • Continuous research funded since 1993 by the NHLBI, NCI, AHRQ, VA, and CDC • Nationally and internationally recognized for work in quality health care measurement and patient outcomes improvement • Associate Editor of the Annals of Epidemiology (1995-2000) • Co-Editor-in-Chief of Medical Care • Afounding Senior Scholar in the VA National Quality Scholars Fellowship • Mentored over 60 post-doc trainees & junior faculty • Catarina.Kiefe@umassmed.edu

  23. John Keaney, MD • Professor of Medicine & Physiology • Chief-Division of Cardiovascular Medicine • Internationally recognized expert on vascular & endothelial cell biology • Research involves biochemical, cellular, animal & human manifestations of vascular disease • NIH funded since 1995, including Multidisciplinary Training in Cardiovascular Research grant • Mentored over 25 post-doc fellows, graduate & medical students, & cardiology fellows http://www.umassmed.edu/faculty/show.cfm?faculty=1219

  24. Katherine Luzuriaga, MD • Professor of Pediatrics & Molecular Medicine • Director-Clinical Research Scholars (K12) Program • Internationally recognized for Informing • understanding of viral & host factors influencing • the establishment of persistent viral infections • (HIV, CMV, and EBV) in infants & children • First to characterize the ability of young infants to generate virus-specific CD8 T cell responses & to demonstrate the efficacy of early antiretroviral treatment in HIV-infected infants • NIH funded; NIH Mid-Career Award to mentor • graduate students, post-doc fellows, & junior • faculty in patient-oriented research http://www.umassmed.edu/faculty/show.cfm?faculty=296

  25. Craig Mello, PhD • 2006 Nobel Prize in Medicine or Physiology • Howard Hughes Medical Institute Investigator • Blais University Chair in Molecular Medicine • Director-RNAi Therapeutics Institute • Internationally recognized as co-discoverer of RNAi, a process & state-of-the-art method by which scientists “knock-out” or silence the expression of specific genes to identify the gene’s function • Mentored more than 40 post-doc fellows & graduate students http://www.umassmed.edu/faculty/show.cfm?faculty=240

  26. John L. Sullivan, MD • Vice Provost for Research • Director-UMass Center for Clinical & Translational Science • Professor of Pediatrics & Molecular Medicine • Internationally recognized for pioneering use of • nevirapine to reduce HIV maternal-to-fetal trans- • mission in sub-Saharan Africa • Ongoing research focuses on immunopathogenic • consequences of HIV infection & pathogenesis of • herpes virus infection • NIH funded more than 25 years • Mentored 6 graduate students & 12 post-doc • fellows http://www.umassmed.edu/faculty/show.cfm?faculty=302

  27. Gyongyi Szabo, MD, PhD • Professor of Medicine • Associate Director-Medical Scientist Program • Director-Clinical/Translational Research • Pathway for Medical Students • Internationally recognized authority on the role • of innate immunity in liver disease • NIH funded since 1990 • Research includes animal models & patients with hepatitis C infection, alcoholic & non-alcoholic • liver disease • PI on the HALT-C multi-center NIDDK-supported • clinical trial • Mentored 18 post-doc fellows http://www.umassmed.edu/faculty/show.cfm?faculty=303

  28. Carole Upshur, EdD • Professor of Family Medicine & Community Health • Associate Dean-Clinical & Population Health Research • Nationally known researcher on the integration of primary care & mental health services, organization & management of behavioral health care for children, & treating chronic pain in primary care • Funded through AHRQ, NIMH, Robert Wood Johnson & Annie E. Casey Foundations, & Health Foundation of Central Massachusetts • Mentored over 30 doctoral students http://www.umassmed.edu/faculty/show.cfm?faculty=658

  29. Zhiping Weng, PhD • Professor of Biochemistry & Molecular Pharmacology • Director-Program in Bioinformatics & Integrative Biology • Known for contributions in two areas— transcriptional regulation & protein-protein interaction • PI on National Human Genome Research Institute grant to computationally predict & experimentally test transcriptional factor binding sites in the human genome (part of the International Consortium called Encyclopedia of DNA Elements (ENCODE) • Mentored more than 30 trainees http://www.umassmed.edu/faculty/show.cfm?faculty=1263

  30. Phillip Zamore, PhD • Howard Hughes Medical Institute Investigator • Gretchen Stone Cook Professor of Biomedical Sciences • Professor of Biochemistry & Molecular Pharmacology • International leader in the study of RNAi & other RNA silencing pathways • NIH funded; High Q Foundation grant to develop • therapies for Huntington’s disease • Pew Scholar in Biomedical Sciences; W.M. Keck • Foundation Young Scholar in Medical Research; • Schering Plough Award • Mentored more than 25 trainees, including medical and graduate students, PhD/MDs, & post-doc fellows http://www.umassmed.edu/faculty/show.cfm?faculty=224

  31. Douglas Ziedonis, MD, MPH • Professor of Psychiatry • Chair-Psychiatry • International expert on co-occurring mental illness & addiction, in particular tobacco dependence & including developing innovative programs, research training, & policy • NIH funded through NIMH, NIDA, & CSAT • Senior Fellow, SAMHSA’s Co-Occurring • Disorders Center for Excellence • Norman H. Edelman Clinical Sciences Mentoring Award • Developed “Training the Mentor” programs http://www.umassmed.edu/faculty/show.cfm?faculty=1247

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