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Core Laboratory of Population Genetic Polymorphisms 族群遺傳核心實驗室

National Taiwan University Center for Genomic Medicine 台大基因體醫學中心. Core Laboratory of Population Genetic Polymorphisms 族群遺傳核心實驗室. 負責人：陳為堅 于明暉. Rationale. Population-based epidemiological studies to unravel the genetics of complex diseases Linkage analysis vs. association study

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Core Laboratory of Population Genetic Polymorphisms 族群遺傳核心實驗室

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  1. National Taiwan University Center for Genomic Medicine 台大基因體醫學中心 Core Laboratory of Population Genetic Polymorphisms族群遺傳核心實驗室 負責人：陳為堅于明暉

  2. Rationale • Population-based epidemiological studies to unravel the genetics of complex diseases • Linkage analysis vs. association study • Research strategies • Either candidate gene approach or genome-wide screen • Single nucleotide polymorphism (SNP) • Large-scale population-based association studies

  3. Overall Goal • To establish a system for recruiting a large number of individuals with DNA and phenotypic data that will be useful for future genetic dissection of complex diseases

  4. Specific Aims • 200,000 blood samples and questionnaire data collection • DNA bank establishment • Specific genetic variants identification • Examination of association between various diseases and specific genetic markers

  5. Methodology • Subjects recruitment • Biospecimen bank • Data collection and management • Follow-up • Data linkage with National Health Insurance Database

  6. Lab Facility • Controlled Rate Freezing System and Liquid Nitrogen Storage System (微電腦控制自動充填液態氮保存系統) • Forma Scientific, Bioway 7460 • -70˚C Freezer • Database • National Mortality Database • Cancer Registry Database • National Health Insurance Database

  7. Interaction with Other Labs • Interaction with Laboratory of Bioinformatics • Handling of massive data and Extraction of information from the large-scale population database • Interaction with Laboratory of Microarray and Gene Chip • DNA subjected to genotyping • Interaction with Other Laboratory • Relevant analyses of genes

  8. Lab Services • Long-term storage and computerized management of DNA • In liquid nitrogen tank • DNA extraction training for research assistants • Good quality that lasts long • Linkage between large-scale database systems • Mortality Database, Cancer Registry Database, National Health Insurance Database

  9. Significance of Lab • Quantifying the impact of various genetic variants on the risk of disease in terms of attributable risks in different ethnic groups • Assessing the validity of new genetic tests in different ethnic groups • Evaluating the impact of genetic tests on morbidity, mortality and cost in different ethnic groups

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