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Y. Oscars 2013. M.H.C. TLRs. Presenting... an antigen!. 1 00. 100. 100. 100. 100. 20 0. 200. 200. 200. 200. 3 00. 300. 300. 300. 300. 4 00. 400. 400. 400. 400. 500. 500. 500. 500. 500.

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  1. Y Oscars 2013 M.H.C. TLRs Presenting... an antigen! 100 100 100 100 100 200 200 200 200 200 300 300 300 300 300 400 400 400 400 400 500 500 500 500 500

  2. Most antibodies are found in the this group of globulins which are the 3rd fastest migrating.

  3. What are gamma globulins?

  4. IgG molecules are cleaved by this enzyme to form 2 Fab fragments and 1 Fc fragment.

  5. What is papain?

  6. These two antibodies are the best complement activators.

  7. What are IgM and IgG?

  8. This heavy chain is expressed on the surface of pre-B cells, associated with surrogate light chains, and is absent in an autosomal recessive form of agammaglobulinemia.

  9. What is the μ heavy chain?

  10. This is the CDR with the most variability.

  11. What is CDR3?

  12. This Best Picture nominee was based on a fable by Yann Martel that stars a tiger and a 16 year old boy.

  13. What is The Life of Pi?

  14. This Best Picture nominee was based on a novel by Victor Hugo and stars a reluctant criminal.

  15. What is Les Misérables?

  16. This Best Picture nominee stars the youngest Best Actress nominee in history.

  17. What is Beasts of the Southern Wild?

  18. This 2013 Best Picture nominee stars “Katniss” from the Hunger Games and “Phil” from the Hangover.

  19. What is Silver Linings Playbook?

  20. This Best Picture nominee chronicles the hunt for Osama Bin Laden and stars Jessica Chastain.

  21. What is Zero Dark Thirty?

  22. This is the name of the set of MHC alleles present on each chromosome.

  23. What is a haplotype?

  24. These two chains make up MHC class I.

  25. What is an α chain and β2 microglobulin?

  26. Peptides are transported into the ER for Class I loading by this molecule

  27. What is TAP?

  28. This segment of class II molecules contain the binding site for CD4.

  29. What is the β2 segment?

  30. This cytokine is encoded in the MHC

  31. What is TNF α, lymphotoxin α or lymphotoxin β?

  32. This TLR binds LPS.

  33. What is TLR4?

  34. These 4 TLRs are expressed on endosomes.

  35. What are TLRs 3, 7, 8, 9?

  36. This TLR does not signal through MyD88.

  37. What is TLR3?

  38. Polymorphisms in this “CARD carrying” member of the NLRs is associated with Crohn’s disease.

  39. What is NOD2?

  40. This enzyme is induced after ligation of TLRs and functions to reduce oxygen in reactive oxygen species.

  41. What is NADPH (or phagocyte) oxidase?

  42. It is an accessory molecule on this cell that binds to CD80/CD86.

  43. What is CD28 on T cells?

  44. Cytokine receptors signal through this pathway.

  45. What is Jak/STAT?

  46. In TCR signaling, Lyk phosphorylates ITAMs on ζ chains in order to provide a docking site for this tyrosine kinase.

  47. What is ZAP-70?

  48. The B cell equivalents of Lck/ZAP-70 are these.

  49. What are Lyn/Syk?

  50. After IP3 mediated calcium liberation from the ER, STIM1 induces the opening of this channel to allow calcium influx into the cell.

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