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  2. figure5 Clinical characteristics of patients TTD1RO and TTD1DOD.a, Alternating light and dark ('tiger tail') pattern of the hairshaft of TTD patient TTD1DOD, as observed using polarizing light microscopy. This pattern is characteristic for the brittle hair of TTD, due to the reduced content of cysteine-rich matrix proteins that are involved in cross-linking of keratin filaments. b, Photograph of TTD patient TTD1RO 10 days after pneumonia. c, Same patient 10 weeks after she lost all hair. figure6 figure7 figure8

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