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Drug Therapy of Urinary Tract Infections

Chapter 85. Drug Therapy of Urinary Tract Infections. Drug Therapy of Urinary Tract Infections. Most common infections Upper Acute pyelonephritis Acute bacterial prostatitis Lower Acute cystitis Acute urethral syndrome Recurrent urinary tract infections. Urinary Tract Antiseptics.

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Drug Therapy of Urinary Tract Infections

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  1. Chapter 85 Drug Therapy of Urinary Tract Infections

  2. Drug Therapy of Urinary Tract Infections • Most common infections • Upper • Acute pyelonephritis • Acute bacterial prostatitis • Lower • Acute cystitis • Acute urethral syndrome • Recurrent urinary tract infections

  3. Urinary Tract Antiseptics • Nitrofurantoin (Furadantin) • Methenamine (Mandelamine) • Nalidixic acid (NegGram) • Cinoxacin (Cinobac)

  4. Nitrofurantoin (Furadantin) • Bacteriostatic—low concentrations • Bactericidal—high concentrations • Uses—lower tract UTIs, prophylaxis, recurrent UTIs • Adverse effects • Gastrointestinal effects • Pulmonary reactions • Hematologic effects • Peripheral neuropathy

  5. Methenamine (Mandelamine) • Decomposes into ammonia and formaldehyde denaturing of bacteria • Uses: chronic lower UTIs • Adverse effects • Safe • Well tolerated • Contraindicated – Renal patient – Liver dysfunction

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