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Drug Therapy of Urinary Tract Infections

Explore the most common infections affecting the urinary tract and learn about the uses and adverse effects of urinary tract antiseptics like Nitrofurantoin and Methenamine. Discover treatment options for acute cystitis, prostatitis, and more.

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Drug Therapy of Urinary Tract Infections

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  1. Chapter 85 Drug Therapy of Urinary Tract Infections

  2. Drug Therapy of Urinary Tract Infections • Most common infections • Upper • Acute pyelonephritis • Acute bacterial prostatitis • Lower • Acute cystitis • Acute urethral syndrome • Recurrent urinary tract infections

  3. Urinary Tract Antiseptics • Nitrofurantoin (Furadantin) • Methenamine (Mandelamine) • Nalidixic acid (NegGram) • Cinoxacin (Cinobac)

  4. Nitrofurantoin (Furadantin) • Bacteriostatic—low concentrations • Bactericidal—high concentrations • Uses—lower tract UTIs, prophylaxis, recurrent UTIs • Adverse effects • Gastrointestinal effects • Pulmonary reactions • Hematologic effects • Peripheral neuropathy

  5. Methenamine (Mandelamine) • Decomposes into ammonia and formaldehyde denaturing of bacteria • Uses: chronic lower UTIs • Adverse effects • Safe • Well tolerated • Contraindicated – Renal patient – Liver dysfunction

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