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References. 1-Gray’s anatomy 2-Human nervous system Noback 3- Basic clinical neuroanatomy Young 4- Head and neck anatomy Berkovitz 5- clinical neuroanatomy Snell. Anatomical division of nervous system. 1- CNS brain and spinal cord 2- PNS peripheral nerves
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References • 1-Gray’s anatomy • 2-Human nervous system Noback • 3-Basic clinical neuroanatomy Young • 4- Head and neck anatomy Berkovitz • 5- clinical neuroanatomy Snell
Anatomical division of nervous system • 1- CNS brain and spinal cord • 2- PNS peripheral nerves ganglions receptors
Cells in this system • 1- neuron • 2-neuroglia • A- Central neuroglia • Macroglia (astrocyte,oligodendrocyte) • Microglia • Ependymal cells • B- Peripheral neuroglia • Schwann cells • Satellite cells
Specialist cell • 1- produce action potential • 2- convey
central neuroglia • Macroglia (astrocyte,oligodendrocyte) • Microglia • Ependymal cells
Peripheral neuroglia • 1- schwann cell • 2- satellite cell
Three points about division of neural tube cells 1- Synchronise formation of neuronal and glial cells. 2- Continuous of glial division after stopping of neuronal cell division. 3- Early formation of large neuron in comparison with small neuron.
Formation of three layers in the thickness of NEURAL TUBE لایه حاشیه ایی لایه اپاندیمی لایه پوشاننده
Neuronal cell migration • 1- Gene activation • 2- Epigenetic signals (mechanical or contact guidance)
Neuronal cell aggregation Morphological appearance • NCAMs (nerve cell adhesion molecules) • N cadherin
Neuroblast differentiation • Apolar neuroblast • Bipolar neuroblast • Unipolar neuroblast • Multipolar neuroblast
Neuroblast differentiation Neurotrophic Factors • 1- NGFs ( Nerve Growth Factors) • 2- Outgrowth Promoting proteins ( Laminin, Netrin, Fibronectin) 3-NCAMs
Cell Programmed Death • Apoptosis • 30 to 60 percent of cells survive
Effects of Experience and Activation on neurons • Structural Plasticity • Axonal sprouting • Changes in the number of Dendritic Spines • Amblyopia Disease
Formation of brain and spinal cord • 1- Primary vesicles • 2- Flexures
Formation of brain and spinal cord • 1- secondary vesicles
Ventricular spaces and central canal • 1-Telencephalon------ lateral ventricals1&2 • 2-Diencephalon-------third ventricle • 3-Mesencephalon----cerebral aqueduct • 4- Rhombencephalon--- forth ventricle • 5-Spinal cord----- central canal • 6- in the end of spinal cord----- terminal ventricle • Monro Foramen(interventricular F)