290 likes | 511 Views
Making and Erasing Memories. Richard L. Huganir Department of Neuroscience Johns Hopkins University School of Medicine Howard Hughes Medical Institute. The Brain is a Network of 100 Billion Neurons. The Brain has Quadrillions of Synapses. Synaptic Transmission.
E N D
Making and Erasing Memories Richard L. Huganir Department of Neuroscience Johns Hopkins University School of Medicine Howard Hughes Medical Institute
Sensory Stimulation Recruits Receptors to Synapses Control Stimulation 0 hour 1 hour 2 hour 3 hour
Spatial Learning - Water Maze Before Training After Training
Fear Extinction: a Form of Behavioral Therapy Extinction Learning
Fear Extinction: a Form of Behavioral Therapy Extinction Learning Extinction Retrieval
Fear Extinction: a Form of Behavioral Therapy Extinction Learning Extinction Retrieval Relapse
24 Hrs window after Fear Conditioning mGluR1-Dependent LTD
Positive Allosteric Modulators of mGluR1 PAM Ro-0711401: 9H-xanthene-9-carboxylic acid (4-trifluoromethyl-oxazol-2-yl)-amide
Huganir Lab Olof Lagerlof Trisha Lala Brain Loeper Bian Liu Richard Roth Raja Sekhar Kamal Sharma Gek Ming Sia Mengnan Tian Alyssa Toda Lenora Volk Rebecca White Yong Zhang Yoichi Araki Shu-Ling Chiu Monica Coulter Kirsten Bombach Min Dai Graham Diering Huaqiang Fang Hana Goldschmidt Ahleah Gustina Lisa Hamm Seok Heo Ingie Hong Natasha Hussain Richard Johnson
Funding HHMI NINDS NIMH Simons Foundation ADRC Pilot Grant