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Tablet Coating

Tablet Coating. Why coat tablets? Types of coatings sugar coating film coating press coating (compression coating). Sugar Coating. stages involved: sealing of tablet core subcoating smoothing colouring polishing printing. Film Coating.

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Tablet Coating

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  1. Tablet Coating • Why coat tablets? • Types of coatings • sugar coating • film coating • press coating (compression coating) CHEE 440

  2. Sugar Coating • stages involved: • sealing of tablet core • subcoating • smoothing • colouring • polishing • printing CHEE 440

  3. Film Coating • Involves spraying a solution of polymer + pigments + plasticizers onto a rotated, mixed tablet bed to form a thin, uniform film on tablet surface. • materials • polymers • solvents • plasticizers • colorants CHEE 440

  4. Coating Process • coating pans CHEE 440

  5. The Coating Process CHEE 440

  6. Film Formation latex particles dispersed in aqueous phase formation of thin film with water evaporation through film continuous film CHEE 440

  7. Air Flow CHEE 440

  8. Coating Process • fluid beds CHEE 440

  9. Important Processing Parameters • inlet and bed temperatures • relative humidity • atomization air pressure • liquid spray rate • droplet size • drying time CHEE 440

  10. Coating Problems • picking/chipping • roughness • sticking • film cracking/peeling CHEE 440

  11. Normal Coating CHEE 440

  12. Enteric-coated • Coating resists dissolution or disruption in stomach but not in intestines. Used for drugs that are unstable, irritating to stomach CHEE 440

  13. Press Coating • Use of compression to form coat around a pre-formed core. • Used mainly to separate chemically incompatible materials • also dual release patterns possible CHEE 440

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