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Zero-Order Kinetic Release From Capsule Reservoirs through Semi-Permeable Polymer Membranes

Zero-Order Kinetic Release From Capsule Reservoirs through Semi-Permeable Polymer Membranes. Denise Bion , Matthew Blank, Dylan Freas , Craig Gambogi , Demetris Rotsides , Sadik Shahidain , Daniel Ye, Barbara Zhan Dr. David Cincotta , Amanda Garfinkel. Controlled-Release Kinetics.

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Zero-Order Kinetic Release From Capsule Reservoirs through Semi-Permeable Polymer Membranes

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  1. Zero-Order Kinetic Release From Capsule Reservoirs through Semi-Permeable Polymer Membranes Denise Bion, Matthew Blank, Dylan Freas, Craig Gambogi, DemetrisRotsides, SadikShahidain, Daniel Ye, Barbara Zhan Dr. David Cincotta, Amanda Garfinkel

  2. Controlled-Release Kinetics • Study of the rates of chemical processes • Most are naturally first or second-order • Zero-order reactions usually do not occur spontaneously • “Pseudo-zero-order reactions”

  3. Applications of Controlled-Release Kinetics • Very effective • medical treatment • Prevents drugs from reaching near-toxic levels (such as those in chemotherapeutic treatments) • Helps maintain • safe but effective concentrations

  4. Polymers • Series of repeated monomer units  long chains • Many properties affect permeability: • Chain length • Chain branching • Intermolecular forces • Different properties result in different diffusion rates

  5. Microspheres (Nanyang Experiment) • BSA loaded into microspheres • Drug Immobilized in PEG membrane • Microsphere acts as an unlimited reservoir • BSA diffuses over a long period of time

  6. Fick’s Law Fick’s Law goes against the concept of a zero-order release mechanism Constant concentration  pseudo-zero-order release

  7. Hypothesis Constant vapor pressure  zero-order release Goal: To create a zero-order release mechanism http://apollo.lsc.vsc.edu/classes/met130/notes/chapter7/cond_pure_sat.html

  8. Hansen Solubility Parameters Ra2 = 4(δ D1 - δ D2) 2 + (δ P1 - δ P2) 2 + (δ H1 - δ H2) 2 RED > 1 : Insoluble RED < 1 : Soluble

  9. Methods and Material VEGETABLE CAPSULES Membrane Liquid Liquid GEL CAPSULES Petri Dish Liquid

  10. Final Experiment Membrane Liquid 2 mL Petri Dish

  11. Overview • 3 polymer membranes, 2 organic solvents, 2 types of capsules • 9 combinations of solvent, capsule, and membrane tested • 12-hour experimental window • Systems were massed every two hours

  12. Error Analysis • Rubber band flaw • Cool down every two hours for massing • Excess membrane • Few data points due to long duration of diffusion

  13. Conclusion • Pseudo-zero-order release w/ capsules and membrane is possible • Many combinations exhibited strong, linear releases • Our model justifies microsphere experiment

  14. Future Studies • Capsules relevant to biological systems • Further experiments on controlling rate of release

  15. Acknowledgements • Dr. David Cincotta, advisor • Amanda Garfinkel, assistant • Dr. David Miyamoto, director • NJGSS and sponsors, providing the opportunity for this experience

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