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Natalia Toporikova Denise Monti Carmen Wright Suzanne Hizer

Adapting published research data to a bioinformatics module in a undergraduate biology major’s course Nature. 2011 May 26;473(7348): 519-22 Long-term evolution and transmission dynamics of swine influenza A virus. Vijaykrishna D, ET AL. Natalia Toporikova Denise Monti

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Natalia Toporikova Denise Monti Carmen Wright Suzanne Hizer

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  1. Adapting published research data to a bioinformatics module in a undergraduate biology major’s course Nature. 2011 May 26;473(7348):519-22Long-term evolution and transmission dynamics of swine influenza A virus.VijaykrishnaD, ET AL. Natalia Toporikova Denise Monti Carmen Wright Suzanne Hizer

  2. A research question to define the problem space • What changes occurred in the swine flu virus that allowed it to infect humans as H1N1 virus?

  3. Identify the primary influenza gene that is responsible for influenza to bind to it’s host cell. • Using MeSH terms to find primary research articles

  4. What does this gene/protein do?

  5. The PDB: more than just structures

  6. How is your gene different or the same between swine and human H1N1?

  7. Exploring the ‘math’ behind multiple sequence alignments http://www.hiv.lanl.gov/content/sequence/HIV/REVIEWS/2006_7/ABECASIS/abecasis.html

  8. Using PYTHON to demonstrate simple sequence alignment algorithm

  9. Identify the variable regions on the protein structure for your gene

  10. How do you think these changes are responsible for H1N1 infectivity in humans?

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