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Lab Exam

Lab Exam. Linkage & Mapping. Chromosomal Basis of Inheritance. Independent Assortment. Parental Types. Special dihybrid with b + and vg + on same chromsome . Recessive “Blank Slate”. Parental Types. Recombinant Types. 2-Locus Test Cross.

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Lab Exam

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  1. Lab Exam

  2. Linkage & Mapping

  3. Chromosomal Basis of Inheritance

  4. Independent Assortment

  5. Parental Types Special dihybrid with b+ and vg+ on same chromsome Recessive “Blank Slate” Parental Types Recombinant Types 2-Locus Test Cross “Expected” assumes Independent Assortment

  6. Parental Types Special dihybrid with b+ and vg+ on same chromsome Recessive “Blank Slate” Parental Types Recombinant Types Deviation from Expected

  7. Linkage

  8. Frequency of Recombination

  9. Constructing Genetic Maps

  10. Gender & Sex Linkage

  11. Gender Determination

  12. Sex-Linkage (in mammals)

  13. Sex-Linkage Inheritance Patterns Dominant or Recessive Sex-Linked Inheritance?

  14. Hemophilia in the Russian Royal Family

  15. Dosage Compensation & Nondisjunction

  16. Barr Bodies & Dosage Compensation

  17. Nondisjuction

  18. Common Aneuploidies • Polyploidies (e.g., in plants) are actually less serious than one too many (or one too few) autosomes • Most abnormalities in numbers of autosomes (anueploidies) are very serious or fatal due to gene dosage imbalances • The fewer genes unbalanced, the less serious the condition • Down’s syndrome: Caused by a trisomy of chromosome number 21 (1 in 700 births)—mental retardation, mongoloid features, and heart defects • Most abnormalities of sex chromosomes do not affect survival • Klinefelter Syndrome: Males with an extra X chromosome (XXY) (1 in 1000 male births) • Turner Syndrome: Females missing one X chromosome (XO) (1 in 2500 female births)

  19. Down Syndrome

  20. XO – Turner Syndrome Turner Syndrome (XO), Incidence: 1 in 2500 female births

  21. XXY – Klinefelter Syndrome Klinefelter Syndrome (XXY), Incidence: 1:1000 male births

  22. Super Male

  23. Additional Complications

  24. Translocation Chromosomal Rearrangements

  25. Genomic Imprinting

  26. Cytoplasmic Inheritance

  27. Link to Next Presentation

  28. Acknowledgements http://207.233.44.253/wms/reynolmj/lifesciences/lecturenote/bio3/Chap09.ppt http://www.ucl.ac.uk/~ucbhjow/medicine/RGD_lectures/modes_of_inheritance.ppt http://www.bbchs.k12.il.us/Teacher_Pages/Hammond/Powerpoint/Chapter_14.ppt

  29. Sex-Linkage (in Drosophila)

  30. Down Syndrome

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