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E lectrical P roperty E valuation T echnology (EPET); Breast Cancer Detection

E lectrical P roperty E valuation T echnology (EPET); Breast Cancer Detection [A UWM-Aurora-NovaScan Joint Project]. William D Gregory, PhD, PE UWM and NovaScan, LLC (CSO). UWM: J. Shell, PhD ; Prof. V. Raicu, PhD. Aurora: J. Marx, PhD ; W. Mikkelson, MD;J. Tjoe, MD.

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E lectrical P roperty E valuation T echnology (EPET); Breast Cancer Detection

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  1. Electrical Property Evaluation Technology (EPET); Breast Cancer Detection [A UWM-Aurora-NovaScan Joint Project] William D Gregory, PhD, PE UWM and NovaScan, LLC (CSO) UWM: J. Shell, PhD; Prof. V. Raicu, PhD Aurora: J. Marx, PhD; W. Mikkelson, MD;J. Tjoe, MD NovaScan: L. Wells, CEO; C. Gregory, PhD Commercialization: TechStar, WiSys, Voith Consulting Telaric, CAMCARE, WIBHT,WI DOC Governor’s BP Contest Dedicated with gratitude to our selfless patient volunteers!

  2. Membrane Current Interstitial Fluid Protoplasm Cell Impedance (V/I) of Tissue (Collection of Cells) NovaScan, LLC – Confidential April 2008

  3. R3 R1 Cm Impedance of Tissue (Cells), cont. Cell Interstitial Fluid NovaScan, LLC – Confidential April 2008

  4. NovaScan EPET I NovaScan, LLC – Confidential April 2008

  5. 4-Lead Probe Tissue Probe Set-Up EPET I Apparatus NovaScan, LLC – Confidential April 2008

  6. Cole Function NovaScan, LLC – Confidential April 2008

  7. Cole Plot Results Cancer Benign NovaScan, LLC – Confidential April 2008

  8. Analyzed two ways: 1) Fc from fit to data below @ 100kHz to the Cole function and 2) peaks for data corrected for loading and roll-off effects NovaScan, LLC – Confidential April 2008

  9. Cell Membrane* *Bioimpedance & Bioelectricity Basics, S. Grimnes and O. G. Martinsen, Academic Press (2005) NovaScan, LLC – Confidential April 2008

  10. NovaScan, LLC – Confidential April 2008

  11. NovaScan EPET II NovaScan, LLC – Confidential April 2008

  12. Vtop=1.0 -1.0 … Vleft …+1.0 -1.0 … Vright …+1.0 Vbottom=-1.0 EPET Algorithm Electrodes Gel Interface charges • Two principles: • Charges only at interfaces • Electrode charges give unique • charge distribution inside NovaScan, LLC – Confidential April 2008

  13. EPET Convergence1,2,3 1.Theory: Gregory, W D & Gregory, C W in Eng. in Med. and Bio. Soc., Proc. of the 22nd Int. Conf. of IEEE, 4, 2632 – 2635, 23-28 July 2000 2.Experiment: “The use of charge-charge correlation in impedance Measurements: a test of the EPET method”, Gregory, C W, PhD thesis, Morgantown WV, 2005 3.Theory & Experiment: “Device for Improved Cancer Detection: Computer Model and Experimental Test with Phantoms”, W Gregory, C Gregory, P Voith and S Kroeger, Technical Report (NovaScan, LLC, February, 2006) NovaScan, LLC – Confidential April 2008

  14. Sensor Plate (16x16) Drive Plane EPET II Apparatus NovaScan, LLC – Confidential April 2008

  15. Breast Cancer Determining Lesion Depth Signal Intensity Cranial-Caudal Caudal-Cranial NovaScan, LLC – Confidential April 2008

  16. Spatial Confirmation Lateral View Medial View NovaScan, LLC – Confidential April 2008

  17. Mass #1 Mass #2 EPET II Results EPET L-breast EPET scan in ML orientation. Mass #1 is poorly differentiated invasive ductal carcinoma; mass #2 is metastatic carcinoma involving lymph node tissue. NovaScan, LLC – Confidential April 2008

  18. EPET II Results NovaScan Findings Thresholds (@ 4 Scans Taken/Patient) 1 = Benign tissue includes FA, BBD, I Pap 2= Cancerous tissue includes IDC/DCIS+, DCIS, ILC/DCIS+ or IDC/LCIS or LCIS, IDC/DCIS- NovaScan, LLC – Confidential April 2008

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