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Chapter 14 Hallucinogenic Drugs. Mescaline Peyote cactus. Psilocybin Psilocybe mushrooms psilocybin psilocin. LSD. Pharmacology of Hallucinogenic Drugs. Pharmacology of Hallucinogenic Drugs. LSD Trip (psychological effects) Onset Plateau Peak Come-down.
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Pharmacology of Hallucinogenic Drugs LSD Trip (psychological effects) • Onset • Plateau • Peak • Come-down
Pharmacology of Hallucinogenic Drugs Physiological effects • Activate sympathetic nervous system • Dilated pupils • Heart rate increase • Blood pressure increase • Body temperature increase • Dizziness • Nausea and vomiting
Pharmacology of Hallucinogenic Drugs Most hallucinogens are 5-HT receptor agonists If you use a 5-HT receptor antagonists together with a hallunicongen, illusions and hallucinations disappear
Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue
Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue
http://www.antidrug.health.am/img/haluc.jpg Pharmacology of Hallucinogenic Drugs Problems with hallucinogenic drugs • “Bad Trip” • Flashbacks • Psychotic breakdown
Dissociative Anesthetics Ketamine crystals
PCPSelf-administration of PCP into the nucleus accumbens shell by rats
KetamineKetamine administration produces a dose-dependent increase in psychotic-like symptoms