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Biorefineries: From Crops to Cash

Genencor's Broad Vision. We envision a future where biotechnology fulfills many unmet needs

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Biorefineries: From Crops to Cash

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    1. Biorefineries: From Crops to Cash Georg Anderl Director of Operations, Market Development April 10, 2006

    2. Genencor’s Broad Vision We envision a future where biotechnology fulfills many unmet needs… In development and deployment of industrial enzymes In the production of fuels, chemicals and materials We envision a future where biotechnology helps create sustainable industrial activities We envision a future where biorefineries take their place alongside oil refineries

    4. Genencor’s Global Presence

    6. Genencor’s Products In Everyday Life Innovative and Cost Effective Catalysts for Many Major Industrial Segments Cleaning Textiles Starch Processing Fuel Ethanol Brewing Leather Baking Pulp and Paper Food and Specialties Biomass (coming soon)

    7. Benefits of the Biobased Economy Economic Reduce cost, better control of product properties New product and market opportunities Improved balance of trade and energy independence Environmental Pollution prevention, reduced emissions of GHG and toxics ‘Green’ fuels, chemicals and materials Reusable and recyclable products Social Rural economic diversification and growth Developing countries can access the biobased economy Improvements in human/environmental health and quality of life

    8. Record Growth Continues — U.S. Fuel Ethanol Production (1980 – 2012)

    9. Oil Product Consumption by Region

    10. Why Biomass? Why the Midwest? Where Else?

    11. Sources of Cellulosic Biomass

    12. Renewable Carbon: Theoretical Ethanol Yields Feedstock Ethanol Yield/Dry Ton* Gallons Liters Cane Bagasse 112 424 Corn Stover 113 428 Rice Straw 110 416 Forest Thinnings 82 310 Hardwood Sawdust 101 382 Mixed Paper 116 439

    13. Feedstock Composition

    14. Advanced Cellulase Development Program Project Structure and Funding U.S. Department of Energy (DOE) funded >$15 million over a 4-year period beginning in June 2000 Sub-contract through the National Renewable Energy Laboratory (NREL) Genencor contributed ~$5 million Goal: Improved Low Cost Cellulase for Biomass Conversion to Ethanol Original program targeted a 10-fold cellulase cost reduction Program achieved a 30-fold reduction 10 – 20 cents (USD) per gallon on NREL model substrate Awards R&D Magazine, Top 100 Innovations, 2004

    15. Technical Strategy Engineer & recruit improved cellulase components Protein Engineering: Improved thermostability in CBH1 & CBH2 Novel Cellulolytic Activities A. cellulolyticus E1 Develop an enhanced T. reesei production organism to produce all the key activities in one host Strain construction Fermentation & product performance screening Improve the Manufacturing Process to minimize production cost Fermentation & Strain improvement including genomics, mutagenesis and screening

    16. Improving production economics (reduced $/gm enzyme) Improving cellulase performance (reduced gm enzyme/gal EtOH) Route to Lower Cost Biomass Enzymes

    17. Overall Cellulase Cost Reduction

    18. Cellulase cost is no longer the major bottleneck in cellulosic biomass conversion The Barrier Has Fallen

    19. Biomass Value Chain Integration

    20. Further Issues…. Biorefinery Issues Facing Genencor and Others Supply Chain What will drive raw material availability? What incentives or guarantees will be required? What is “value” of each player’s contribution Whole broth enzyme formulation IP protection Co-location and/or single purpose dedicated facility Demand Chain What in addition to ethanol will provide the best value to investors? What will it take for them to be accepted in the market? Investment What is best mechanism to allow regional/local investors to participate? What is the role of investment types (angel, traditional, etc.) Derisking funds – federal and state (pioneers face huge risk)

    21. Going Forward… Genencor Biomass Business group continuously sorting through numerous requests Aligning with groups that Work at system level Provide funding for development of custom enzyme solutions Demonstrate widely deployable business model

    22. The BIOWA Connection BIOWA is an industry led organization that is an “Integrator” Creating partnerships/alliances for a system level integration Connecting with “derisking” funds Collaborating with academia and other groups to thoroughly address issues

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