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Hamilton Venus Software Intelligent Liquid Sensing

Hamilton Venus Software Intelligent Liquid Sensing. P icture. Intelligent Liquid Sensing . 1. Capacitive Liquid Level Detection ( cLLD ) 2. Pressure Liquid Level Detection ( pLLD ) 3. Anti Droplet Control (ADC ) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD)

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Hamilton Venus Software Intelligent Liquid Sensing

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  1. Hamilton Venus Software Intelligent Liquid Sensing Picture

  2. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  3. Intelligent Liquid Sensing Capacitance Liquid Level Detection • Conditions: • Black tips or needles • Conductive liquids only • Clean or used tips • All channels • 96 head - A1 and H12 only • 384 Head – A5 and P24 only • Aspirate and or dispense steps More Details

  4. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  5. Intelligent Liquid Sensing Pressure Liquid Level Detection • Conditions: • Black / clear tips • Any liquid • Clean tips, aspirate only • All channels More Details

  6. Intelligent Liquid Sensing When to use cLLD & pLLD • Bubbles on liquid surface • Use pLLD to find the liquid surface • cLLD could be triggered by the bubbles • Aqueous layer under organic layer • Use pLLD to find the non-conductive organic layer • Use cLLD to find the conductive aqueous layer

  7. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  8. Intelligent Liquid Sensing Anti-Droplet Control • With ADC – the pressure increase inside the channel is measured and thepiston moved to compensate. • Without ADC – high vapour pressure of volatile liquid results in a pressure increase in the tip forcing the liquid out. • Plunger position

  9. Intelligent Liquid Sensing Anti-Droplet Control • Prevent droplets on tips when pipetting highly volatile liquids • This is a standard feature in VENUS • Conditions: • Black / clear tips or needles • Channels only • Pre-wetting tips improves performance More Details

  10. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  11. Intelligent Liquid Sensing Capacitance Clot Detection • The conductive signal after aspiration is measured. • gap between tip and liquid - the capacitance signal will vanish. • clot - it bridges the gap and the signal remains, resulting in an error message • Conditions: • Black tips or needles • Conductive liquids only • Clean or used tips • All channels More Details

  12. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  13. Intelligent Liquid Sensing Monitored Air Displacement Empty tip Tip in liquid start aspirating Tip filled with correct volume of liquid Pressure Tip filling with liquid under vacuum Correct Aspiration Plunger stops moving, tip continues to fill PressureThreshold Tip blocked Tip Blocked Time

  14. Intelligent Liquid Sensing Monitored Air Displacement • Conditions: • Black / clear tips • Clean tips, aspirate only • All channels • Lower limit varies but >10µl • MAD has only been optimised for aqueous liquids • MAD can be switched on for individual aspiration steps in a method • The pressure threshold can be varied to detect whether each pipetting step was successful More Details

  15. Intelligent Liquid Sensing 1. Capacitive Liquid Level Detection (cLLD) 2. Pressure Liquid Level Detection (pLLD) 3. Anti Droplet Control (ADC) 4. Capacitance Clot Detection 5. Monitored Air Displacement (MAD) 6. Total Aspiration and Dispense Monitoring (TADM)

  16. Intelligent Liquid Sensing Total Aspiration and Dispense Monitoring • TADM increases the safety and robustness of pipetting processes by recording and monitoring pressure throughout the pipetting cycle. It’s main use in in clinical settings where a permanent record showing correct pipetting of every sample is needed. Conditions: • Black / clear tips • Clean tips • All channels • 96 TADM head • Requires additional TADM software

  17. Intelligent Liquid Sensing Total Aspiration and Dispense Monitoring Aspirate Dispense • Various pipetting errors change the pressure curves in interpretable ways

  18. Intelligent Liquid Sensing Total Aspiration and Dispense Monitoring Aspirate Dispense • The user sets both TADM tolerance bands and the required response if they are crossed • Bands are set , using test data, for every liquid, tip type and volume used

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