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Neuroscience and nano -biomedicine through complex networks. Cristian R. Munteanu, Ph.D. Biomedicine Researcher RNASA-IMEDIR, TIC, University of A Coruña http://miaja.tic.udc.es | muntisa@gmail.com. Outlines. Complex Networks (CN) CN in Neuroscience CN in Nano-Biomedicine.
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Neuroscience and nano-biomedicine through complex networks Cristian R. Munteanu, Ph.D. Biomedicine Researcher RNASA-IMEDIR, TIC, University of A Coruña http://miaja.tic.udc.es | muntisa@gmail.com
Outlines • Complex Networks (CN) • CN in Neuroscience • CN in Nano-Biomedicine Neuroscience and Nano-Biomedicine through Complex Networks Cristian R. Munteanu | http://miaja.tic.udc.es | muntisa@gmail.com
Complex Networks (CN) • Network- any group or system of vertices/nodes connected by a common property (nodes: atoms, amino acids, nucleic bases, drugs, proteins, viruses, bacteria, neurons, people, systems, etc.) • Topological Indices (TIs) - numerical parameters of the CN which characterize its topology, geometry or structure TIs codify the INFORMATION about a real network Neuroscience and Nano-Biomedicine through Complex Networks Cristian R. Munteanu | http://miaja.tic.udc.es | muntisa@gmail.com
Complex Networks (CN) Net Matrices Connectivities, node distances, node degrees, node transition probabilities CN with connected neurons Topological Indices (TIs) Classification Models (QSAR, QSPR etc) (using General Discriminant Analysis, Neural Networks, Machine Learning, etc.) Neuroscience and Nano-Biomedicine through Complex Networks Cristian R. Munteanu | http://miaja.tic.udc.es | muntisa@gmail.com
CN in Neuroscience Parcellation of the cat cortex Complex network of region-region co-activation Classification Models, Quantitative Structure-Property Relationships (QSPR) (Linear Discriminant Analysis + Node degree, Values for Centroid, Betweeness for shorted path and HINTS-Hub topological indices) Humberto González-Díaz, Santiago Vilar, Daniel Rivero, Enrique Fernández-Blanco, Ana Porto and Cristian Robert Munteanu, chapter: QSPR models for cerebral cortex co-activation networks, in Topological Indices for Medicinal Chemistry, Biology, Parasitology, and Social Networks, p. 179-189, Transworld Research Network, Kerala, India, ISBN: 978-81-7895-489-9, in press (2010) http://miaja.tic.udc.es
CN in Nano-Biomedicine + Drug Fullerene Fullerene graphs Classification Models Quantitative Structure-Activity Relationships (QSAR) (using Linear Discriminant Analysis, Artificial Neural Networks, Machine Learning, etc.) Neuroscience and Nano-Biomedicine through Complex Networks Cristian R. Munteanu | http://miaja.tic.udc.es | muntisa@gmail.com
Thank you! Cristian R. Munteanu, Ph.D. Biomedicine Researcher RNASA-IMEDIR, TIC, University of A Coruña http://miaja.tic.udc.es | muntisa@gmail.com