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People with specific cancers may go through a stem cell transplant. Graft vs host disease symptoms might appear when the donor cells attack the recipientu2019s cells.
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Graft-versus-host disease (GVHD) occurs when transplanted tissue, such as stem cells, attacks the recipient's body. It's a common complication of bone marrow or stem cell transplants used to treat certain cancers or blood disorders. GVHD can affect the skin, liver, and gastrointestinal tract, leading to various symptoms and complications.
Types of Graft vs Host Disease • Chronic Graft Versus Host Disease • Acute Graft Versus Host Disease
Chronic Graft Versus Host Disease Chronic Graft Versus Host Disease (GVHD) can manifest at any point post-allogeneic transplant, with most cases emerging within a few years. It affects various body parts including the mouth, lungs, muscles, skin, genitals, and more.
Acute Graft Versus Host Disease Acute Graft Versus Host Disease typically occurs shortly after transplantation, often within the first 100 days. Symptoms may appear later and can affect the skin, liver, or gastrointestinal tract.
Causes of Graft vs Host Disease After a transplant, the risk of Graft Versus Host Disease (GvHD) increases. Here, donated white blood cells target the host's cells as foreign. These cells recognize genetic differences, like HLA, akin to fingerprints. GvHD can manifest within 100 days post-transplant, with chronic cases arising later, affecting the skin, liver, and GI tract.
Symptoms of Graft vs Host Disease • Jaundice • Skin rash • Increased risk for infections • Abdominal pain or cramps • Nausea or vomiting • Loss of appetite • Diarrhea • Abnormal liver function
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