1 / 18

NIHBI Launch Event

NIHBI Launch Event. 6 th June 2005 John Stageman VP Information & Sciences, Global Discovery. Short Agenda. Importance and potential impact of NIHBI Current challenges for Pharma R&D Informatics progress in AstraZeneca Current active interfaces Changing boundaries Opportunities.

ura
Download Presentation

NIHBI Launch Event

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NIHBI Launch Event 6th June 2005 John Stageman VP Information & Sciences, Global Discovery World Pharma IT Congress

  2. Short Agenda • Importance and potential impact of NIHBI • Current challenges for Pharma R&D • Informatics progress in AstraZeneca • Current active interfaces • Changing boundaries • Opportunities World Pharma IT Congress

  3. Common challenges for Pharma R&D • Increasing cost and attrition • Decreasing overall productivity • Risk-averse Political and Regulatory environment • Loss of public trust and understanding of positive contribution to human health • Unprecedented technology and science opportunity • Expanding universe of relevant information World Pharma IT Congress

  4. In-house, External, Structured, Unstructured, Tacit, Explicit Public information & Commodity technology Core In-house Collaborations Qs: How will the boundaries move? How to govern information crossing boundaries? How to balance integration in-house vs. external Information? World Pharma IT Congress

  5. Submission HitIdentifica-tion LeadIdentifica-tion LeadOptimisa-tion CDPrenomi-nation Target Identification ConceptTesting Development for launch LaunchPhase Launch Informatics Need Across the R & D Pipeline Bioinformatics, Cheminformatics, Lead Informatics, Discovery Informatics… Clinical Informatics, Medical Informatics, Development Informatics, R&D Informatics…

  6. Paradigm Shift in Biology Leads to Data Explosion • Comprehensive DNA sequence information • Microarray and other measurement technologies • High content biology • -Omics • Genomics • Proteomics • Metabonomics • Lipidomics • Carbodomics • Cellomics • Imaging, Histopathology, etc. World Pharma IT Congress

  7. New Directions in Chemical Research • Combinatorial chemistry • High-throughput synthesis and screening • Chemical mixtures • Structural Genomics and rational design • International data and systems • More compound databases • Virtual screening • Physical and DMPK property modelling World Pharma IT Congress

  8. Robotics and Miniaturization Generate Lots of Data in Discovery R2 = 0.85

  9. More Studies and More Data in Clinical • eClinical: Electronic Data Capture in Clinical trials • Electronic ECG recording and analysis • Biomedical Imaging: MRI, PET scans • Pharmacogenetics • -omics and Biomarkers World Pharma IT Congress

  10. Submission HitIdentifica-tion LeadIdentifica-tion LeadOptimisa-tion CDPrenomi-nation Target Identification ConceptTesting Development for launch LaunchPhase Launch MouseBase Informatics Tools World Pharma IT Congress

  11. Animal Models Tissue Histopath Disease Clinical Data Biomarker Biomedial Image Target Literature DMPK -omic data Make Connections: Build and Visualize Relationships Projects Time Compounds Genes World Pharma IT Congress

  12. Opportunities for Bioinformatics to Impact • Translational Science • Linking Clinical outcome data to target biology • Linking targets and compounds to AEs / liabilities • Molecular markers of disease • Early efficacy and dose response relationships • Animal and human model relationships • Clinical trial • PK/PD modeling and simulations • Adaptive design for clinical trials • Knowledge sharing of disease information across projects World Pharma IT Congress

  13. Specific Areas of focus within Drug Development • Understand Disease, understand drug activity • Disease reclassification • Identification of disease sub-classes • Identification of Biomarkers for disease subclasses. • Biomarkers for early detection. • Patient stratification • Identification of appropriate groups in clinical trials. • Disease staging for treatment options. • Prognosis of disease progression / severity. • Drug mechanism, effect, metabolism and transport • Toxicology and side effects • Dose studies • Efficacy and adverse events World Pharma IT Congress

  14. Drug Discovery Process is Not Really a Linear Process World Pharma IT Congress

  15. Phe Ge Che Must Understand Relationship World Pharma IT Congress

  16. Understanding Complexity of Biological Systems E-CELL -- Masaru Tomita, Keio U. World Pharma IT Congress

  17. Data Links Between Diverse Structures and Processes World Pharma IT Congress

  18. Opportunities in partnership • Rapid progression of systems biology approach to understanding disease mechanisms and drug actions • Common challenges of medical data capture, secure archiving and accessibility for research • Developing the clinical research informatics platform for ‘Ge’+’Phe’+’Che’ correlations • Improving systems for monitoring therapy compliance, impact and safety • Exploring changing the boundaries and paradigms for Phase 3,4 clinical development (can UK/NW lead the world?) • ……+many more! World Pharma IT Congress

More Related