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OBJ 1 i. Anticarcinogenicity-phytochemicals ii. Anticarcinogenicity - dietary indoles iii. Anti-inflammatory/immune-enh

FIGURE 1. MILESTONES. Year. 0 1 2 3 4 5. OBJ 1 i. Anticarcinogenicity-phytochemicals ii. Anticarcinogenicity - dietary indoles iii. Anti-inflammatory/immune-enhancement - natural/induced chemicals iv. Antimicrobial phytochemicals OBJ 2

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OBJ 1 i. Anticarcinogenicity-phytochemicals ii. Anticarcinogenicity - dietary indoles iii. Anti-inflammatory/immune-enh

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  1. FIGURE 1. MILESTONES Year 0 1 2 3 4 5 OBJ 1 i. Anticarcinogenicity-phytochemicals ii. Anticarcinogenicity - dietary indoles iii. Anti-inflammatory/immune-enhancement - natural/induced chemicals iv. Antimicrobial phytochemicals OBJ 2 i.Genotoxicity/carcinogenicity of phytochemicals and heat-generated chemicals ii. Phytoestrogens and tumor growth iii. Immunotoxic effects of natural and induced chemicals OBJ 3 i. Bioactive secondary metabolites from root cultures ii. Bioactive secondary metabolites from from leaf, stem and flower tissue OBJ 4 i.Effects of agricultural practices ii. Effects of food processing Mechanistic animal feeding studies Dose response studies Mechanisms of action Tumor cell gene expression In vitro promoter studies Animal studies Animal -dose response, pure chemicals Animal - natural extracts Collaborative cell /animal studies Structure-function Synergy studies Effect of food processing DNA damage characterization Gene function studies Dose response studies Interactions and cancer therapies Structure-function studies Gene function studies Collaborative cell studies Establish culltures Induction studies/bioassay Bioassay-directed fractionation Bioassay Bioassay-directed fractionation Identification/Analytical Compare conventional,IPM, organic models Evaluate bioactivity potency in vitro Select bioactive chemical candidates Evaluate effects of food processing

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