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Coccidioidomycosis

Coccidioidomycosis. Demosthenes Pappagianis, M.D., Ph.D. University of California, Davis November 2011. New Coccidioidomycosis California Correctional Institutions (CCI) January – September 2011 (UC Davis Coccidioidomycosis Serology Lab).

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Coccidioidomycosis

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  1. Coccidioidomycosis Demosthenes Pappagianis, M.D., Ph.D. University of California, Davis November 2011

  2. New Coccidioidomycosis California Correctional Institutions (CCI)January – September 2011(UC Davis Coccidioidomycosis Serology Lab)

  3. Domingo Escurra -First patient with Coccidioidomycosis (1892)

  4. Domingo Escurra

  5. Joao SilveiraSecond case, recognized in California (1894)

  6. Dye Creek Coccidioidomycosis - California Endemic Areas Soledad Paso Robles Avenal Coalinga Calif. Men’s Colony Corcoran Otay Tecate

  7. Archeology students - California

  8. Transmission of Coccidioidomycosis Human to Human CASE SOURCE OUTCOME REFERENCE Mortician abraded skin of finger while embalming Expired patient with disseminated coccidioidomycosis Spread from finger to epitrochlear and axillary lymph nodes survived no therapy Wilson et al., 1953 House staff (3), nurses (3) Patient with disseminated coccidioidomycosis of knee; organism grew on and dispersed from plaster of Paris cast dispersing arthroconidia Survived; none disseminated Eckmann et al., 1964 Neonate Mother with coccidioidomycosis of endometrium and cervix Mother survived, infant died Bernstein et al., 1981 Neonates (twins) Mother with disseminated disease, transplacental Mother died, infants died Shafai, 1978 Neonate Mother with disseminated coccidioidomycosis of cervix of uterus infected amniotic fluid Infant died; mother survived 5 years Larwood, 1962 Donor with pulmonary coccidioidomycosis Survived Tripathy et al., 2002 Human with transplanted lung Human with transplanted kidney Human with transplanted liver Wright et al., 2003 Fatal Donor with (unknown) prior disseminated coccy Fatal “ “ Human with transplanted lung Donor with quiescent coccidioidomycosis of lungs Fatal Miller et al., 2004 Female with pelvic/ abdominal coccy Husband’s semen – artificial insemination Living

  9. H. Chope 1929

  10. Coccidioidal Erythema Nodosum

  11. Night sweats, Anorexia ( Pappagianis 1998)

  12. Coccidioidomycosis - Spectrum of Disease

  13. Woman with Chronic Coccidioidal Cavity – Right Lung

  14. Mannose binding lectin?

  15. Time to Dissemination

  16. Coccidioidal Basilar Meningitis H. Einstein

  17. CSF compartments

  18. ?

  19. ,(-) skin tests

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