1 / 22

HAART has been shown to decrease HIV transmission • Vertical (MTCT) Setting • Heterosexual Sero-discordant Couples •

HAART has been shown to decrease HIV transmission • Vertical (MTCT) Setting • Heterosexual Sero-discordant Couples • Injection Drug Users Cohort • Mathematical Models. Unique Study Features: • Population Based • Free Access to HAART and Medical Monitoring

urian
Download Presentation

HAART has been shown to decrease HIV transmission • Vertical (MTCT) Setting • Heterosexual Sero-discordant Couples •

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. HAART has been shown to decrease HIV transmission • Vertical (MTCT) Setting • Heterosexual Sero-discordant Couples • Injection Drug Users Cohort • Mathematical Models

  2. Unique Study Features: • Population Based • Free Access to HAART and Medical Monitoring • Centralized Data Capture / Single Source • Access to Blood Borne Dxs – BCCDC • Retrospective & Prospective Phases

  3. January 2004 Summer of 1996 Summer of 1996 Phase I Phase II Phase III Year Montaner et al, Lancet, June 18th 2010

  4. Incidence/yr Acquired resistance falling 90 80 70 60 Plasma viral load suppression rising Viral load < 50/mL (%)

  5. Population Plasma HIV-1-RNA % <500 copies/mL

  6. Highest HIV-1- Plasma Viral load per Year Non IDU IDU Ever on Treatment & Censoring at the time of Death or Move The proportion of HIV infected IDUs engaged in care in BC with plasma viral load >1500 c/mL, as a surrogate for “high” community HIV-1-viral load, decreased from ~50% in 2000-04 to ~20% in 2009 (p<0.001) Montaner et al, Lancet 2010

  7. “Provincial Viral Load” All Patients Ever Tested for Plasma HIV-1-Viral Load in BC Censoring at the time of Death or Move

  8. Number of HIV tests per Year in BC 1994 2000 2008 BC-CDC Report, 2009

  9. Hepatitis C, 1999-2008 Infectious Syphilis, 1999-2008 2004 • BC • BC 2004 x Canada x Canada Genital Chlamydia, 1999-2008 Gonorrhea, 1999-2008 x Canada • BC x Canada • BC 2004 2004

  10. Key Findings: Overall correlation between the number of pts on HAART and the number of new HIV cases diagnosed per year was -0.89 (p<0.0001) For every 100 additional patients on HAART, the number of new HIV cases decreased by a factor of 0.97 (95% CI 0.96-0.98) • ie: new HIV diagnoses fell by 3%. For every 1 log10 decrease in viral load, the number of new HIV cases decrease by a factor of 0.86 (95% CI 0.75-0.98)

More Related