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Virology 1

Virology 1. PM2 Pathophysiology. Virus. infectious particle DNA or RNA as its genetic material. Needs to infect a host cell for replication “toxic”, “poison” virology. Tobacco mosaic virus. Baltimore classification of viruses. based on the mechanism of mRNA production.

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Virology 1

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  1. Virology 1 PM2 Pathophysiology

  2. Virus • infectious particle • DNA or RNA as its genetic material. • Needs to infect a host cell for replication • “toxic”, “poison” • virology Tobacco mosaic virus

  3. Baltimore classification of viruses • based on the mechanism of mRNA production. • I: dsDNA viruses Adenoviruses, Herpesviruses, Poxviruses • II: ssDNA viruses (+)sense DNA Parvoviruses • III: dsRNA viruses Reoviruses • IV: (+)ssRNA viruses (+)sense RNA Picornaviruses, Togaviruses • V: (-)ssRNA viruses (-)sense RNA Orthomyxoviruses, Rhabdoviruses • VI: ssRNA-RT viruses (+)sense RNA :Retroviruses • VII: dsDNA-RT viruses :Hepadnaviruses

  4. Icosahedral

  5. Helical viruses • not grouped in capsomeres • ribbon-like structure

  6. Complex

  7. Start

  8. Forms of damage to the host cells • 1. Cell lysis • 2. Production of toxic substances • 3. Cell transformation • 4. Induction of formation of substances • 5. Induction of structural alterations in the host cell ; Nuclear (including chromosomal) or Cytoplasmic changes

  9. PRIONS • Contain protein only • small, proteinaceous particles • Kuru • Creutzfeldt-Jakob disease syndrome

  10. DNA VIRUSES • Herpes Virus • Hepatitis B virus • Adenovirus • Parvovirus • Polyomavirus • Papillomavirus

  11. herpes simplex virus type 1 herpes simplex virus type 2 varicella-zoster virus Cytomegalovirus Epstein-Barr virus human herpesvirus 6 human herpesvirus 7 Kaposi's Sarcoma herpesvirus. Herpesvirus

  12. HSV • Causes encephalitis • DOC: Acyclovir

  13. Varicella (chickenpox)

  14. Herpes Zoster

  15. CMV: 3 types of infections • 1. Congenital cytomegalovirus infection retinitis petechial/purpuric skin rash central nervous system defects • 2. Mononucleosis syndrome fever, malaise, atypical lymphocytosis, pharyngitis • 3. immunocompromised individuals life-threatening disease from either primary or reactivated infection

  16. EBV • Epstein-Barr virus mononucleosis: most common that occurs in humans. • Infectious mononucleosis • Most cases: subclinical, (+) serology • Main cause of malignant B-cell lymphoma in organ transplants • PTLD:post-transplant lymphoproloferative disorder

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