1 / 20

Muscle Physiology: Understanding Sarcomere Protein Components

This discussion delves into the structural components of muscle fibers, including the sarcomere, its proteins, and their functions, focusing on titin, actinin, desmin, and the dystrophin-glycoprotein complex. Learn about the physiological anatomy of muscle and the clinical significance in muscular dystrophies.

vancebrian
Download Presentation

Muscle Physiology: Understanding Sarcomere Protein Components

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NERVE MUSCLE PHYSIOLOGY Dr FarzanaSalman

  2. OBJECTIVES • At the end of this discussion you should be able to: • 1.Know the structural components of a muscle fiber • 2. Differentiate striated muscles & correlate it with structural components. • 3. Know the major types & functions of Proteins present in a muscle fiber

  3. Types of Muscles SimilaritiesDifferences • Skeletal. Excitability. . Structure Contractility . Location • Cardiac. Elasticity. . Function Activation • Smooth. . Contraction

  4. Physiological anatomy of MUSCLE Muscle Fascicle

  5. Physiological anatomy of MUSCLE

  6. SARCOMERE “Structural and functional Unit of the Muscle” Mainly Comprised of: Actin Filaments Arranged between two Z lines Myosin Filaments Besides these ?

  7. SARCOPLASM • Spaces between the myofibrils are filled with intracellular fluid called sarcoplasm. • Potassium • Magnesium • Phosphate • Protein enzymes • Mitochondria

  8. Sarcomere (Supportive Proteins) 1. Titin, 2. Actinin, 3. Desmin & 4. Dystrophin-Glycoprotein complex

  9. SARCOMERE Proteins • Titin: MW= 3 million Largest springy protein Provides scaffolding for the sarcomere Connects Z line to M line • Actinin : MW=190,000 Binds actin to Z line • Desmin: Binds Z line to plasma membrane

  10. Dystrophin-Glycoprotein Complex • Large Protein, MW = 427000 • Forms a Rod which connects the Actin filament to the transmembrane Protein Beta-Dystroglycan in the sarcolema. • Function: Adds strength to the muscle by providing a Scaffolding for the fibrils & connecting them to the Extra cellular Matrix

  11. Dystrophin-Glycoprotein Complex Merosin

  12. CLINICAL SIGNIFICANCE • Musculardystrophies. Diseases that cause progressive weakness of skeletal muscle 1) Duchenne muscular dystrophy. 2) Becker muscular dystrophy.

More Related