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Genetic Disorders Review

Genetic Disorders Review. What is the disorder?. Chromosome 11 Inability to manufacture melanin Often shifting back and forth of eyes ANSWER: ALBINISM. What is the disorder?. Polygenic More common among Asians Opening in lip and roof of mouth ANSWER: cleft lip/cleft palate.

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Genetic Disorders Review

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  1. Genetic Disorders Review

  2. What is the disorder? • Chromosome 11 • Inability to manufacture melanin • Often shifting back and forth of eyes • ANSWER: ALBINISM

  3. What is the disorder? • Polygenic • More common among Asians • Opening in lip and roof of mouth • ANSWER: cleft lip/cleft palate

  4. What is the disorder? • Sex-linked trait • Lack AHF factor • “bleeder’s disease: • ANSWER: hemophilia

  5. What is the disorder? • Chromosome #4 • Too many copies of CAG – causes atrophy of the brain • Does not manifest itself until 20’s-30’s • ANSWER: Huntington’s

  6. What is the disorder? • On X-chromosome • Weakening of muscles • Calf muscles enlarge first, usually in young boys • ANSWER: Duchenne Muscular Dystrophy

  7. What is the disorder? • Chromosome #15 • Accumulation of fat on the brain leads to degeneration of the nervous system • Highest in Eastern European Jews • ANSWER: Tay Sachs

  8. What is the disorder? • Nondisjunction • XXY • Sterile, small testes, breast enlargement in males • ANSWER: Klinefelters

  9. What is the disorder? • Nondisjunction • Trisomy 21 • Mental retardation, round face, extra fold on eyes, sluggish muscles • ANSWER: Down Syndrome

  10. What is the disorder? • Chromosome #12 • Breakdown of products of phenylalanine • Mental retardation if diet does not omit phenylalanine • ANSWER: PKU

  11. What is the disorder? • Red blood cells collapse • Carriers are somewhat resistant to malaria • Found mostly in African-Americans and people of Mediterranean • ANSWER: sickle-cell anemia

  12. What is the disorder? • Nondisjunction • Female XO, sterile • Web between neck and shoulders • ANSWER: Turner Syndrome

  13. What is the disorder? • Sex-linked trait • XcY would be affected male • Inability to detect certain colors • ANSWER: color blindness

  14. What is the disorder? • Dominant chromosome #4 • Short stature, trident hand, prominent forehead • Dwarfism Aa • ANSWER: Achrondroplasia

  15. What is the disorder? • Dementia • Memory loss, confused • Plaque on the brain • ANSWER: Alzheimers

  16. What is the disorder? • Long limbs, enlarged aorta • Spidery fingers • Abe Lincoln had it • ANSWER: Marfans

  17. What is the disorder? • Polygenic trait • Shunt in brain to drain off fluid • Opening of the vertebral column • ANSWER: Spina bifida

  18. What is the disorder? • Chromosome #7-salty skin in symptom • Lack enzyme to break down mucous in respiratory and digestive tract • Treatment with pounding chest • ANSWER: Cystic Fibrosis

  19. What is this diagram called? • Pedigree • Punnett square • C.Kayrotype

  20. What is this diagram called? • Punnett square • Pedigree • C.Kayrotype • ANSWER: C

  21. What is this diagram called? • Punnett square • B. Pedigree • C. Karyotype

  22. What is this diagram called? • Punnett square • B. Pedigree • C. Karyotype • ANSWER: B

  23. What disorder is this? • TURNERS • KLINEFELTERS • DOWNS • METAFEMALE

  24. What disorder is this? • TURNERS • KLINEFELTERS • DOWNS • METAFEMALE • ANSWER: XXY • Klinefelters

  25. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE D. DOWNS

  26. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE D. DOWNS ANSWER: D

  27. What are the chances of… • two Achrondroplasia parents having a normal sized child? • HINT: AA = dead • Aa = achondroplasia • aa = normal • ANSWER: 25%

  28. What are the chances… • Of a father with hemophilia and a wife of no hemophilia gene having a child with hemophilia? Could any children be carriers? • ANSWER: 0% children; girls are carriers

  29. What disorder is this? A. TURNERS B. KLINEFELTERS C. METAFEMALE D. DOWNS ANSWER: A

  30. Klinefelters Turners Cystic Fibrosis Trisomy 21 Hemophilia ANSWERS: Cystic Fibrosis Hemophilia Which disorders ARE NOT caused by nondisjunction?

  31. What is the genotypic ratio of the offspring of parents AO and BO? A O B O

  32. What is the genotypic ratio of the offspring of parents AO and BO? A O B O What is the phenotypic ratio?

  33. What is the genotypic ratio of the offspring of parents AO and BO? A O B O What is the phenotypic ratio? 25% each blood types A, B, AB, O

  34. A+ O+ O- AB+ B- O+, A+ Only O+ Only O- All + O-, B- What type of blood can each of these blood types RECEIVE?

  35. In which phase of mitosis • Are the chromosomes stopped to make a karyotype? • A. prophase • B. telophase • C. metaphase • D. anaphase • ANSWER: METAPHASE

  36. How are the chromosomes arranged • In a karyotype? • A. smallest to largest • B. largest to smallest • C. by color • D. by shape • ANSWER: B

  37. Who is the oldest child in generation III?

  38. Who is the oldest child in generation III? • #1

  39. If red hair is recessive and is shaded in, how many boys and how many girls have red hair?

  40. If red hair is recessive and is shaded in, how many boys and how many girls have red hair? • 2 boys + 2 girls

  41. Is this person a male or female?

  42. Is this person a male or female? • MALE

  43. Is this person male or female?

  44. Is this person male or female? • MALE • Normal Or what Disorder?

  45. Is this person male or female? • MALE • Klinefelters

  46. Is this a male or female?

  47. Is this a male or female? • Female- Normal or a disorder?

  48. Is this a male or female? • Female- TURNERS SYNDROME

  49. This is a sex-linked trait. Why is there no trait (shaded) in Generation II, but can be in III?

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