40 likes | 139 Views
Medical Microbiology. Chapter 67 - Prions. Prions. Proteinaceous infectious particles with no known genetic material! Diseases – Box 67-1 These are all neurodegenerative diseases These all have very long incubation periods (up to 30 years for the human diseases)
E N D
Medical Microbiology Chapter 67 - Prions
Prions • Proteinaceous infectious particles with no known genetic material! • Diseases – Box 67-1 • These are all neurodegenerative diseases • These all have very long incubation periods (up to 30 years for the human diseases) • These proteins elicit no immune response, are extremely resistant to inactivation by heat, disinfectants, and radiation. • Formaldehyde, UV radiation, heat up to 80º C
Prions • Infection cycle – Figure 67-1 • Transmission: • Injection • Transplanted tissue • Contaminated medical devices • Food • Box 67-3 • Stories of kuru and vCJD • Box 67-4