Slides last updated: October 2013

1. Slides last updated: October 2013

2. Lung cancer incidence and mortality Lung cancer is one of the most common cancers, with 1.6 million new cases per year worldwide1 Lung cancer is the most common cause of death from cancer, responsible for 18.2% of all cancer deaths1 • Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013.

3. Rates of lung cancer incidence and mortality differ worldwide1 Northern America Central and Eastern Europe More developed regions Eastern Asia Micronesia Western Europe Polynesia Northern Europe Southern Europe Australia/New Zealand World South-Eastern Asia Less developed regions Caribbean Southern Africa Western Asia South America Central America Melanesia Northern Africa South-Central Asia Eastern Africa Western Africa Middle Africa 55% of new lung cancer cases occur in developing countries Highest lung cancer rates are found in Northern AmericaLung cancer is the most common cancer in men and the second most common in women Lowest lung cancer rates are found in Middle AfricaLung cancer is the 15th most common cancer Incidence Mortality Male Female 80 60 40 20 0 20 40 60 80 Estimated age-standardized rates (World) per 100,000 • Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013.

4. Rates of lung cancer incidence differ between men and women1 Lung Prostate Colorectum Stomach Liver Oesophagus Bladder Non-Hodgkin lymphoma Leukaemia Lip, oral cavity Kidney Pancreas Larynx Brain, nervous system Other pharynx Breast Cervix uteri Colorectum Lung Stomach Corpus uteri Ovary Liver Thyroid Leukaemia Non-Hodgkin lymphoma Oesophagus Pancreas Brain, nervous system Kidney Lung Lung 1092056 948993 515999 427586 Incidence Mortality 40 30 20 10 0 0 10 20 30 40 ASR (W) rate per 100,00 ASR (W) rate per 100,00 Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013.

5. 100 B reas t c a nc e r 80 Co l o - recta l 60 c an ce r Pro s t a t e 40 c an ce r High unmet medical need 20 Lun g c an ce r 0 1975 2004 Survival rates for lung cancer are generally low1 Five-year survival trend Survival rates vary depending on stage at diagnosis. The later the stage of diagnosis the lower the survival rates tend to be. PERCENTAGE (%) 1. SEER. Fast Stats Online. 5 year survival by diagnosis. 1975-2004. All races. All ages. Male and Female. Available online: seer.cancer.gov/faststats/selections.php, accessed on 15/09/2013.

6. NSCLC makes up approximately 85% of lung cancer1 Large cell carcinoma (2.6% of lung cancer) Lung Cancer (100%) Other NSCLC (20.2% of lung cancer) Squamous cell carcinoma (21.4% of lung cancer) Adenocarcinoma (40.1% of lung cancer) NSCLC (85.3% of lung cancer) • Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013.

7. The distribution of NSCLC subtypes is changing1 Since the 1980’s, squamous cell carcinomas have become relatively less common Meanwhile, adenocarcinomas have become relatively more common The reasons for these changes are unclear, but may be due to changes in the composition and filtering of cigarettes 1. Devasa S, Bray F, Vizcaino A, et al. Int. J. Cancer 2005: 117, 294–299