Fig. S1

1. LayS38 LayS39 LayS40 LayS41 LayS42 LayS44 LayS45 LayS46 LayS47 LuloRGD LayS38 LayS39 LayS40 LayS41 LayS42 LayS44 LayS45 LayS46 LayS47 LuloRGD 54 54 54 54 54 54 54 54 54 60 67 67 67 67 67 67 67 67 67 76 MNKIILLSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFPALVFCAE------AMPKESVNILNTENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFLALVFCAE------AMPKESANILNAENEPDDTVDIDEGLPDAFEEDYE MNKIILFSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFEEDYE MNKIILFSAVFLALVFCAE------AMPRESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFVALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILLSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MKLFCLIFVVFVALEVCIETVKAMEATEEISVKLQDDANEPDDSLDLDEGLPDAFDEDYN -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -RDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- NQAEYKPNP-RGDYRRR * * Fig. S1

2. * * * * LayS48 LayS49 LayS50 LayS51 LayS52 LayS53 LayS54 LayS55 LayS56 LayS58 LayS59 LayS60 LayS61 LayS62 LayS63 LayS64 LayS65 LayS66 LayS67 LayS68 LayS69 LayS70 LayS71 LayS72 LuloSL1 LayS48 LayS49 LayS50 LayS51 LayS52 LayS53 LayS54 LayS55 LayS56 LayS58 LayS59 LayS60 LayS61 LayS62 LayS63 LayS64 LayS65 LayS66 LayS67 LayS68 LayS69 LayS70 LayS71 LayS72 LuloSL1 MKYQCFVLIAIFFWIGQSRAENPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILRCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRGVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYPCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVSGNEKNKLFDHIKACA MKCQCFVLIAIFFWIGQSRAERPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKKKLFDHIKACA MKYPCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVLGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVSGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEERCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLLDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENCRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGRSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVLGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAEHPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAVPGNEKNKLLDHIKACA MNHLCFIIIALFFLVQQSLAEHPEEKCIRELARTDENCILHCTYSYYGFVDKNFRIAKKHVQKFKKILVTFDAVPKKEKKKLLEHIEACA DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDA DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DTANATKPKSHNDKCYKIIHYYRCVVDGKILSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKILSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYCRCVVDGKILSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKILSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DTANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKNV DAANATKPKSHNDKCYKIIHYYRCVVDGKVLSWNSYAAAIIKYDKTKDV DSANADQPQTKDEKCTKINKYYRCVVDGKILPWNSYADAIIKFDKTLNV 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 90 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 139 * * Fig. S2

3. * * * LayS32 LayS33 LayS34 LayS36 LayS37 PpeSP09 LayS32 LayS33 LayS34 LayS36 LayS37 PpeSP09 LayS32 LayS33 LayS34 LayS36 LayS37 PpeSP09 60 60 60 60 60 58 120 120 120 120 120 118 143 143 143 143 143 141 MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD MSFLFFLVALISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD M--NYFVAVLISAVFLARSCQGDHPEAKCIRDFKDKNPACIIHCKYNFYKFTDDKFSINE QHINKFTDILIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI QHINKFTDILIKNKAVDGSKKSQVQEHLKKCTEESLKKTHGKNCQRLVEYYSCAVDNKLI QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI EHMRKLTDILIKYKAVDAAEKARVEKHLRKCKEEATQKSKTPSCERILYYYSCLVDLRLI DYFKYESAINSYDRTIYTPPYSG DYFKYESAINSYDRSIYTPPYSG DYFKYESAINSYDRTIYTPPYSG DYFKYESAINSYDRTIYTPPYSG DYFKYESAINSYDRSIYTPPYSG DYYKYNDAMKTYDNTIYLSRFSN * * * Fig. S3

4. A MKLFLLVFTGILFQGILGVEITQGYKWRQILYGDVTPGTYNPDTNIPTAFAHDADGHKLFLTIPRKFPKIPHTLAEVDTEKNPGVSGKRS MKLFLLVFTGILFQGILGVEITQGYKWRQILYGDVTPGTYNPDTNIPTAFAHDADGHKLFLTIPRKFPKIPYTLAEVDTEKNPGVSGKRS MKLFLLVFTGILFQGILGVEITQGYKWRQILYGDVTPGTYNPDTNIPTAFAHDADGHKLFLTIPRKFPKIPYTLAEVDTEKNPGVSGKRS MKVFFSIFTLVLFQGTLGAD-TQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHS PLLNRFSGHKSGNELTSVYQPVIDDCRRLWVVDVGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRHHFPVRLVEKPTYFGGFAVDV PLLNRFSGHKSGKELTSVYQPVIDDCRRLWVVDVGSVEYRSRSAKDYPSHRPAIVAYDLKQPNYPEVVRYHFPVRLVEKPTYFGGFAVDV PLLNRFSGHKSGKELTSVYQPVIDDCRRLWVVDVGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYHFPVRLVEKPTYFGGFAVDV PLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDV VNPTGDCSETYVYITNFLSNALFIYDHKNQQSWNVTDATFKAERPSTFDHQGKQYTYKAGLFGITLGDRDKDGNRPAYYLAGSSIKVYSV VNPTGDCSETYVYITNFLSNALFIYDHKNQQSWNVTDATFKAERPSTFDHQGKQYTYKAGLFGITLGDRDKDGNRPAYYLAGSSIKVYSV VNPTGDCSETYVYITNFLSNALFIYDHKNQQSWNVTDATFKAERPSTFDHQGKQYTYKAGLFGITLGDRDKDGNRPAYYLAGSSIKVYSV ANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSV NTKELKQKNKKLNPELLGNRGKLNDAIALAYDPKTKGIFFAESKTRQVSCWNTQKMPLRMQHTDVIYSNTRFVFGTDISVDSKGTLWFMS NTKELKQKNKKLNPELLGNRGKLNDAIALAYDPKTKVIFFAESNTRQVSCWNTQKMPLRMQHTDVIYSNTRFVFGTDISVDSKGTLWFMS NTKELKQKNKKLNPELLGNRGKLNDAIALAYDPKTKVIFFAESNTRQVSCWNTQKMPLRMQHTDVIYSNTRFVFGTDISVDSKGTLWFMS NTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVD--------- NGFPPVKNSQKFKFDYPRYRLLNVDTQAAIAGTNCEIKPR NGFPPVKNSQKFKFDYPRYRLLNVDTQAAIAGTNCEIKPR NGFPPVKNSQKFKFDYPRYRLLNVDTQAAIAGTNCEIKPR ---------------------------------------- LayS22 LayS23 LayS24 LJM11 LayS22 LayS23 LayS24 LJM11 LayS22 LayS23 LayS24 LJM11 LayS22 LayS23 LayS24 LJM11 LayS22 LayS23 LayS24 LJM11 90 90 90 90 180 180 180 180 270 270 270 270 360 360 360 350 400 400 400 350 * * * * B LayS118 LJM17 LayS118 LJM17 LayS118 LJM17 LayS118 LJM17 LayS118 LJM17 90 90 177 180 266 270 356 360 405 412 * * * * Fig. S4

5. LayS8 LayS9 LayS10 LayS11 LayS12 LayS13 LayS14 LayS16 LayS17 LayS18 LayS19 LayS20 LayS21 LuloAPY LayS8 LayS9 LayS10 LayS11 LayS12 LayS13 LayS14 LayS16 LayS17 LayS18 LayS19 LayS20 LayS21 LuloAPY LayS8 LayS9 LayS10 LayS11 LayS12 LayS13 LayS14 LayS16 LayS17 LayS18 LayS19 LayS20 LayS21 LuloAPY LayS8 LayS9 LayS10 LayS11 LayS12 LayS13 LayS14 LayS16 LayS17 LayS18 LayS19 LayS20 LayS21 LuloAPY MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MLLKLWIFTMATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVGKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLRIFTLATALLVQVSKSAPPGVEWYHFGLIADMDNKAITPSDRNTFNTILNIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPNDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMDKKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKWVVCAFATVFLVGVSQAAPPGVEWYHFGLIADMDKKSIA-SDKTTFNSVLKIDELRHNTKTDQYIYVRSRVKKPVSTRYGFKGRGA ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKYDKIYAGSTGITFKDEKGNANTQSLWVKEITKGG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFNAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRTTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLSNGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVEEITKDG ELSEILVFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWAKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKRPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVNEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVRNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFDKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEIVVFNNKLYTVDDKSGITFRITKDGKLFPWVILADADGQRPDGFKGEWATIKDDTIYVGSTGMLK-------FTSSLWVKKITKDG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPKQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVKDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPGKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG VVTSHDWTDKYRKILKALNMPN-GFVWHEAVTWSPFRKQWVFMPRKCSRHPFSQELEERTGCNKIVTADENFNDIQVIHIQDQPYNLASG FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGSQKK----------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD-------- FPAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVRKNKFRLKKLNLKK FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD-------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGIPFFWGNQKNKFH-------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYERVAFFGGSQEK----------- FSAFKFIPGQNNEKLLALRTIEQGDKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD-------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYERIPFFWGSQKNKVRLKD----- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPEPKLYDEKYEGVAFFGGSQKK----------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYNEKYEGVAFFRGNQKK----------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPEAKLYDEKYEGVAFFGGIKKNKSD-------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGSQEK----------- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVIIDMEGNVLMPERKLYDEKYERVAFFGGSQEK----------- FSSFRFIPGTKNERLLALRTVEQEDQVKTWAVVMDMKGTVLMYEKELYDEKFEGLAFFGGIKKN----------- 90 90 90 90 90 90 90 90 90 90 90 90 90 90 180 180 180 180 180 180 180 180 180 180 180 180 180 172 270 270 270 270 270 270 270 270 270 270 270 270 270 261 334 337 345 337 337 334 337 340 334 334 337 334 334 325 Fig. S5

6. * * * LayS95 LayS96 LayS97 LayS98 LayS99 LayS100 LayS101 LayS102 LayS103 PpeSP04b LayS95 LayS96 LayS97 LayS98 LayS99 LayS100 LayS101 LayS102 LayS103 PpeSP04b LayS95 LayS96 LayS97 LayS98 LayS99 LayS100 LayS101 LayS102 LayS103 PpeSP04b MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASEETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPSSDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASEETDCYVKCVWKNLGSYNDADDSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPVSDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF MNALFLLCVLLSLGELGYSWQYPRNADQTLWAFRSCQREGKNPDLVKKWMNWELPNDRETHCYVKCVWIHLGSYNHNKHSIKIDKVKNQF RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKDVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPTSLQKVAGPTSGSCKDVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS SSRGVQIPPELEKIGGPTSGSCKDVYDKTIAFFKSQKTNLQKAYYGTKEDSNKWYSENPDTKPKGTKISVFCKDKNREGGKEGTCKHSCS MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY MYYYRLVDEDNLVIPFRKLPGISESDLKECRDAASKKTGCKVADEIYECLHNVNRKGFEDALKKLDGESAVY 90 90 90 90 90 90 90 90 90 90 175 175 175 175 175 175 175 175 175 180 247 247 247 247 247 247 247 247 247 252 * * * * * * * Fig. S6

7. LayS83 LayS84 LayS85 LayS86 LayS87 LayS89 LayS90 LayS91 LayS92 LayS93 Lulo 29.2kDa LayS83 LayS84 LayS85 LayS86 LayS87 LayS89 LayS90 LayS91 LayS92 LayS93 Lulo 29.2kDa LayS83 LayS84 LayS85 LayS86 LayS87 LayS89 LayS90 LayS91 LayS92 LayS93 Lulo 29.2kDa LayS83 LayS84 LayS85 LayS86 LayS87 LayS89 LayS90 LayS91 LayS92 LayS93 Lulo 29.2kDa MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDNS--DVYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGS MLKEIFFLALLVAVAQCANEIPINQQGKNYP-PIADPDKS--DDYFDDRFYSDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPVAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFVLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MIKEVFSLALLVALAQCANEIPINRQGKDYPVPIIDPNKSSSDDYFDDRFYPDIDDEGIAEAPKDNRGKSRGGGAAGAREG--RLGTNGA TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGRTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTKPSASGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGG-------GTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGG-------GTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPG-------GGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSASGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- KPGQGGTRPGQGGTRPGQGGTRPGQGGTRPGQGGTRPGQGRTKPAQGTTRPAQGTRNPGSVGTKEAQDASKQGQGKRRPGQVGGKRPGQA ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIIDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEVIDGDPSGLGLAVQTI ---AAGGRKQGAKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGAKGTKGANRRSDLSKYKDFPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVPTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEHTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIIDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIIDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKNSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKIPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI NAPNAGTRKQ-QKGSRGVGR-PDLSRYKDAPAKFVFKSPDFSGEGKTPTVNYFRTKKKEHIVTRGSPNDEFVLEILDGDPTGLGLKSETI GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILENPKGNNIVGRVKIYRGAYTG GKDSRLILKIPKGTTLWAV---------- GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRDAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDTRLVLENPNGNSIVARVKIYKNGYSG 88 88 88 87 88 88 88 88 88 88 88 165 165 165 164 158 158 158 165 165 165 178 252 252 252 251 245 245 245 252 252 252 266 281 281 281 270 274 274 274 281 281 281 295 Fig. S7

8. * * * * LayS73 LayS74 LayS75 LayS76 LayS77 LayS78 LayS79 LayS80 LayS81 Lulo Ag5 LayS73 LayS74 LayS75 LayS76 LayS77 LayS78 LayS79 LayS80 LayS81 Lulo Ag5 LayS73 LayS74 LayS75 LayS76 LayS77 LayS78 LayS79 LayS80 LayS81 Lulo Ag5 89 89 89 89 89 89 89 89 89 90 179 179 179 179 179 179 179 179 179 180 270 270 270 270 270 270 270 270 270 271 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMDKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKSKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQSAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLVVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNPLVKIHNRLRDRFAKGAVPGFQSA MLQIKHLLIFVGLLVVVNAQSNYCKQESCSSGGVERPHIGCKNSGDFSETCSGDAEIVKMDKKKQNLLVKMHNRLRDRFARGAVPGFAPA AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQVMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTEDYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDGLAKLEEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTGNYVGGPGAGGK AKIPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRAIDVCPYAGQNLAQMMSYPTHRDLNYVLKNLTREWFWEYRWAKQSQLDNYVGGPGKDNK QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNCCYTNMLKEKIYTKGKPCSECQSKKCGPVYRNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGRPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLRDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARFTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEQSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG QIGHFTAFVHEKTDKVGCAIARFTNEHNFKETLLACNYCYTNMMKERIYTQGKPCSQCQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKHGK * * * * * * * * Fig. S8

9. LayS120 LayS121 LayS122 LayS123 LayS124 LayS125 LayS126 LayS127 LayS128 LayS129 LayS130 LayS131 LayS132 Lulo 16.5kDa LayS120 LayS121 LayS122 LayS123 LayS124 LayS125 LayS126 LayS127 LayS128 LayS129 LayS130 LayS131 LayS132 Lulo 16.5kDa 87 87 87 87 87 87 87 87 87 87 87 87 87 90 159 159 159 159 159 159 159 159 159 159 159 159 159 160 MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKCNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWMGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSETFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVFKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHLLAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLSLTFLTLRTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHLLAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNTYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MNLHLAIILFVSYFTLITATDLIEKELSDCKKIFISKAELTWFQALDFCTEQNLTLLSIKSARENDEVTKAVRAEVHLPDTKKSHIWLGG YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPDN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATNKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEVYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFRDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC IRYDQ---DKDFRWISDGTTVTKTVYINWYQGEPNGGRYQKEFCMELYFKTPAG---QWNDDICTAKHHFICQEKK * * * Fig. S9

10. MNKIILISLALAVLGLCIQAKPRDTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIASF MNKIILISLALAVLVLCIQAKPRDTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIASF MNKIILISLALAVLVLCIQAKPRDTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIARF MNKIILISLALAVLVLCIQAKPRGTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIASF MRNFAVVSLAVAVLLFCAWP--------INAED-------NEEVGKAREKRGLKDAMEHF TDGFKELIKFELPKFNLPKISGLPGSSGSSDGSSGSSDGSSGSSDGSSG-------GGSD TDGFKVLIKFELPKFNLPKIPGLPGSSGSSDGSSGSSDGSSGSSDGSSGSSDGSSGGGPD TDGFKELIKFELPKFNLPKIPGLPGSSGSSDGSSGSSDGSSGSSDGSSG-------GGSD TDGFKELIKFELPKFNLPKIPGLPGSSGSSDGSSGSS-------DGSSG-------GGSD KNGFKELTK----DFKLPSLPSLPGFGKKPE--SGSSEDSGDKTEDTSG----------- NSKGDSEKSKEQKKD NSKGDSEKSKEQKKD NSKGDSEKSKEQKKD NSKGDSEKSKEQKKD -SKDDQSKDNTVEES LayS4 LayS5 LayS6 LayS7 Lulo 9kDa LayS4 LayS5 LayS6 LayS7 Lulo 9kDa LayS4 LayS5 LayS6 LayS7 Lulo 9kDa 60 60 60 60 45 113 120 113 106 88 128 135 128 121 102 Fig. S10