Study

1. OR Study Treatment Control OR or sub-category n/N n/N 95% CI 95% CI 01 AxSYM Douketis 0/5 0/19 Not estimable Mehta 1/18 1/20 1.12 [0.06, 19.28] Yalamanchili 8/24 9/123 6.33 [2.14, 18.77] Douketis JD 6/62 10/396 4.14 [1.45, 11.82] Subtotal (95% CI) 109 558 4.60 [2.22, 9.54] Total events: 15 (Treatment), 20 (Control) Test for heterogeneity: Chi² = 1.33, df = 2 (P = 0.51), I² = 0% Test for overall effect: Z = 4.10 (P < 0.0001) 02 ECLIA Pruszczyk 8/32 0/32 22.55 [1.24, 409.83] Kostrubiec 9/39 6/61 2.75 [0.89, 8.47] Kaczynska 10/28 6/59 4.91 [1.56, 15.42] 99 152 4.16 [1.92, 9.04] Subtotal (95% CI) Total events: 27 (Treatment), 12 (Control) Test for heterogeneity: Chi² = 2.01, df = 2 (P = 0.37), I² = 0.4% Test for overall effect: Z = 3.60 (P = 0.0003) 03 Elecsys Janata 5/41 0/65 19.74 [1.06, 367.18] Binder 6/46 1/78 11.55 [1.34, 99.27] Kline 2/20 0/161 43.65 [2.02, 944.27] Subtotal (95% CI) 107 304 18.36 [4.06, 83.05] Total events: 13 (Treatment), 1 (Control) Test for heterogeneity: Chi² = 0.49, df = 2 (P = 0.78), I² = 0% Test for overall effect: Z = 3.78 (P = 0.0002) Total (95% CI) 315 1014 5.14 [3.11, 8.47] Total events: 55 (Treatment), 33 (Control) Test for heterogeneity: Chi² = 6.96, df = 8 (P = 0.54), I² = 0% Test for overall effect: Z = 6.40 (P < 0.00001) 0.001 0.01 0.1 1 10 100 1000 Log scale