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Bovine Viral Diarrhea Virus (BVDV) Research Needs and Coordinating Efforts of NCBA, AABP, AVC, and USAHA. January 27, 2009 4 th BVDV Symposium –BVDV Variability: Impact on Virulence, Host Range, and Control. BVDV Research Priorities: Input . NCBA BVD Research Subcommittee 2008
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Bovine Viral Diarrhea Virus (BVDV) Research Needs and Coordinating Efforts of NCBA, AABP, AVC, and USAHA January 27, 2009 4th BVDV Symposium –BVDV Variability: Impact on Virulence, Host Range, and Control
BVDV Research Priorities: Input • NCBA BVD Research Subcommittee 2008 • NCBA BVD Working Group 2008 • Academy of Veterinary Consultants: BVDV committee • AABP BVDV committee • 2008 USAHA Infectious Diseases of Cattle Committee
Priority Item • Knowledge Gap • Approach • Deliverable
BVDV Research Priorities • 1. Assessment of the Economic Impact of BVDV in Beef Production Operations • 2. Design and Evaluation of Surveillance/Control Programs • 3. Surveillance, Identification, and Determination of Significance of Emerging BVDV Subtypes • 4. Development and Critical Evaluation of Diagnostic Tests • 5. Critical Evaluation of Current Vaccines • 6. Development of Innovative New BVDV Vaccines • 7. Investigate the Pathogenesis of BVDV in Cattle Based on Disease Predisposition and Genetics
BVDV Research Priorities • Assessment of Economic Impact of BVD in Beef Production Operations • General economic impact of BVD • Transmission dynamics of PI (Persistently Infected) and TI (Transiently Infected) BVD cattle in production enterprises in relation to economic cost • Morbidity and mortality rate of TI and PI calves in relation to economic cost
Design and Evaluation of Surveillance Programs • Surveillance strategies for early detection of PI BVDV incursion in BVDV negative beef breeding herds and support for herd disease freedom claims • Testing strategies at the ranch, dairy, auction market or feedyard to economically detect positive individuals and herds and to control herd introduction risk • Management strategies for biosecurity and biocontainment to control impact of PI cattle • Role of wildlife as reservoir of exposure and infection for cattle
Surveillance, Identification, and Determination of Significance of Emerging BVDV Subtypes • Detection and confirmation of new BVDV subtypes in the U.S. • Determine if differences among BVDV subtypes affect diagnostic and vaccine performance.
Development and Critical Evaluation of Diagnostic Tests • Validation of diagnostic tests available in the U.S. • Innovative test development
Critical Evaluation of Current Vaccines • Fetal protection challenge studies for all USDA licensed vaccines • Effective models for acute challenge for the postnatal susceptible calf • Duration of immunity after BVDV vaccination
Development of Innovative New BVDV Vaccines • Novel vaccines • Marker vaccines • Adjuvants
Investigate the Pathogenesis of BVDV in Cattle Based on Disease Predisposition and Genetics • Genetics for infectious disease resistance/susceptibility relating to BVDV
Critical Issues Facing BVDV Programs and Various Groups • Definition and agreement on goals of control and eradication • Adequate funding at federal- state levels • Private and corporate , producer organizations • Collaborative research teams • Unified voice on control programs to the producers • Numerous groups already involved • Potential of a national committee with range of participants