1 / 13

Primary Immunodeficiency - Diagnosis and Overview

Learn how to diagnose Primary Immunodeficiency Disorders using history, physical exam, and various tests. Overview of B-Cell and T-Cell system defects. References from reputable sources.

vergies
Download Presentation

Primary Immunodeficiency - Diagnosis and Overview

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Immunodeficiency Disorders University of Jordan School of Medicine Department of Pathology, Microbiology and Forensic Medicine Malik Sallam, MD, PhD

  2. Primary Immunodeficiency (ID)

  3. How to diagnose PID? • Hx & PE. • CBC & differential. • Quantitative Igs. • Review of previous culture results. • Titers for administered vaccines. • Lymph enumeration using FCM. • Skin testing. • CH50, C3 & C4. • Phagocyte studies, NBT. • Enzyme studies.

  4. Overview of the Primary ID

  5. Defects of the B-Cell SystemX-Linked Bruton’s Agammaglobulinemia

  6. Defects of the B-Cell SystemX-Linked Bruton’s Agammaglobulinemia

  7. Defects of the B-Cell SystemSelective IgA Deficiency

  8. Defects of the B-Cell SystemCommon Variable Immunodeficiency

  9. Defects of the T-Cell SystemDiGeorge Anomaly

  10. Defects of the T-Cell SystemHyper IgM Syndrome

  11. Defects of Neutrophil FunctionLeukocyte Adhesion Deficiency

  12. Complement Deficiencies

  13. References • Abbas AK, Pillai S, Lichtman AH. Cellular and molecular immunology. 9th ed. Philadelphia: Elsevier/Saunders; 2018. • Levinson W. Review of medical microbiology and immunology. 13th ed. New York: McGraw-Hill Medical; 2014. • Owen JA, Punt J, Stranford SA, Jones PP, Kuby J. Kuby immunology. 7th ed. New York: W.H. Freeman; 2013. • Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. 1st ed. Baltimore, MD: Lippincott Williams & Wilkins; 2008. • Nairn R, Helbert M. Immunology for medical students. 2nd ed. Philadelphia: Mosby; 2007. • Male D, Brostoff J, Roth DB, Roitt I. Immunology. 7th ed. Mosby/Elsevier; 2006. • Notarangelo LD. Primary immunodeficiencies. J Allergy Clin Immunol2010,125:S182-194. • Modell V, Knaus M, Modell F, Roifman C, Orange J, Notarangelo LD. Global overview of primary immunodeficiencies: a report from Jeffrey Modell Centers worldwide focused on diagnosis, treatment, and discovery. Immunol Res 2014,60:132-144. • ReustCE. Evaluation of primary immunodeficiency disease in children. Am Fam Physician 2013,87:773-778. • Picard C, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, et al. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. J Clin Immunol2015,35:696-726.

More Related