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Learn how adherence is measured in smoking cessation treatment, how patients adhere to treatment, and what predicts adherence. Explore a study on blended treatment and discover different measures and predictors of adherence.
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How do we measure adherence, how do patients adhere and what predicts adherence? Adherence to a blended smoking cessation treatment
ConsortiumRookvrijLeven Technology, Health & Care Lectorate, Saxion University of Applied Sciences Department of Psychology, Health & Technology; University of Twente Department of Pulmonary Medicine; Medical Spectrum Twente Department Online Treatment and Prevention; Tactus Addiction Treatment
Background: Blended Treatment Promising way to deliver behavioral change interventions Combining the strengths of face-to-face (F2F) treatment with the unique features of Web-based care ”Best of both worlds”
Definition: Adherence • Problems in context of counselling: • premature termination of the treatment • failures to complete between session tasks and exercises
Adherenceand Smoking Cessation Treatment • Primary determinant of treatment effectiveness (Dose-Response Relationship) • Measurement • F2F: completed tasks and/or attended sessions • Web: log-ins, module completion, time spend online, messages/emails, print requests … • Adherence rates (smoking cessation) • Widely vary between studies (5%-96%) • Adherencerapidlydeclines, resulting in rather low adherence rates (<40%)
Knownpredictorstoadherence in smokingcessationtreatment • Higher age • Male gender • Higher internet skills • Negative attitude toward smoking and higher motivation to quit at baseline • Higher self-efficacy at baseline • Early success in quitting after the start of the treatment • Lower nicotine dependency at baseline and fewer withdrawal symptoms after quitting
Questions How do we measure adherence? How do patients adhere? What predicts adherence?
Studyparticipants • Subset (N=70) of an RCT on the effectiveness of “Blended Smoking Cessation Treatment” (BSCT) versus Face-to-face-treatment as usual • Outpatient smoking cessation clinic at the Medical Spectrum Twente hospital (Enschede/The Netherlands) • Inclusion criteria • being at least 18 years old, • currently smoking (at least one cigarette a day) • having access to email and internet • being able to read and write Dutch
Studyintervention BSCT A combination of F2F-treatment and Web-based sessions blended into one integrated smoking cessation treatment delivered in routine care settings Consists of 5 F2F sessions at the outpatient clinic and 5 Web-based sessions (50-50 balance between F2F and Web) High-intensity treatment (6h total) derived from the Dutch Guideline Tobacco Addiction, fulfilling the requirements of the Dutch care module for smoking cessation Supports three quitting strategies
Adherence data collection • Minutes-based measure (sum of minutes in treatment based on hospital administration) • Easy • Simple • Time-saving • Features-based measure (patients activities based on patient records and online dossiers) • More in-depth assessment • Identification of weaknesses • Improvement
Agreement between the two measures of assessing adherence (N=70) Adherence based on a threshold (60%) • Dichotom: • Cohen's kappa test showed moderate agreement between the evaluation of adherence using the minutes-based and the features-based measure (κ = .438, p < .001) - agreement in the classification of 51 (72.9%) patients • Continuous: • Adherence assessed using the minutes-based measure was moderately correlated with adherence evaluated using the features-based measure (rho(70) = .529, p < .001)
Method • Same participantsandintervention • N=75 (5 patientsmore) • Adherencebased on feature-basedmeasurement • Self-reported smoking status • 3-month and 6-month follow-up (Web-based questionnaire)
Adherenceto BSCT Adherence based on the threshold (60%)
Method • Same participantsandintervention • N=75 (5 patientsmore) • Adherencebased on feature-basedmeasurement • Patients’ Characteristics • 33 person-, smoking-, and health-related characteristics (intake measurement, Web-based questionnaire)
Predictors in BSCT (online questionnaire) • Sex • Age • Marital status • Housing situation • Education status • Main income • Main day activity • Internet skills • Reason to start treatment • Dependency • Attitude neg • Attitude pos • Self-efficacy • Readiness to quit • Earlier quit attempts • Social support • Social modeling • Medication in general • Medication addiction • Medication psychic • Medication physical • Medication others • Health complaints • Health + smoking related complaints • Depression • Anxiety • Stress • DASS total • Quality of life • Quality of life (VAS)
Univariate • Univariately associated based on the features-based measure (N=75)
Multivariate Multivariate regression analyses • Marital status and social modeling—accounting for 25% of the variance (Nagelkerke R Square)—were independent predictors of whether patients were adherent to BSCT. • Patients having a partner had 11 times higher odds of being adherent (OR=11.3; CI: 1.33 to 98.99; P=.03). • For social modeling, graded from 0 (=partner and friends are not smoking) to 8 (=both partner and nearly all friends are smoking), each unit increase was associated with 28% lower odds of being adherent (OR=0.72; CI: 0.55 to 0.94; P=.02).
Discussion • Both types of measurement agree/correlate with each other. • The features-based measure seems more valid, but is more complicated and time-consuming. • There is a dose response relationship between adherence and quitting (as to be expected). • Adherence to BSCT is rather low, especially for the Web-based parts. • Strength • Adequate measures (promising tools for future research) • Predictors identified (improvement) • Limitation • No comparison to eg. F2F treatment as usual • Indirect assessment of adherence • Low sample size • No “golden standard” to compare with
Literature Siemer, L., Pieterse, M. E., Brusse-Keizer, M. G., Postel, M. G., Allouch, S. B., & Sanderman, R. (2016). Study protocolfor a non-inferioritytrialof a blended smokingcessationtreatment versus face-to-face treatment (LiveSmokefree-Study). BMC publichealth, 16(1), 1187. Siemer, L., Brusse-Keizer, M. G., Postel, M. G., Allouch, S. B., Bougioukas, A. P., Sanderman, R., & Pieterse, M. E. (2018). Blended Smoking Cessation Treatment: Exploring Measurement, Levels, andPredictorsofAdherence. Journal ofmedical Internet research, 20(8). Patrinopoulos Bougioukas, A. (2017). Adherence to blended smoking cessation treatment (Master's thesis, University of Twente).