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Lecture 08 – Second Messengers II – Calcium signaling

Lecture 08 – Second Messengers II – Calcium signaling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. CSB Fig 02:01 Cell signalling pathways . Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 .

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Lecture 08 – Second Messengers II – Calcium signaling

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  1. Lecture 08 – Second Messengers II – Calcium signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  3. Transducers Second Messengers II • Calcium signaling • Cyclic ADPribose • Inositol phosphate & other lipid signaling • PLC – PIP2, DAG • PI3K – PIP3 • PLD – PA

  4. CSB Fig 2:14 Basic Ca2+ signalling mechanism Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  5. CSB Fig 2:15 Ca2+ signalling dynamics Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  6. CSB Fig 2:17 Ca2+ signalling toolkit Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  7. CSB Fig 3:10 Ca2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  8. ROCs • Cysteine-loop receptors • Nicotinic acetylcholine receptors (nAChRs) • 5-Hydroxytryptamine 3 (5-HT3) receptors • γ-Aminobutyric acid (GABA) receptors • Glycine receptors (GlyRs) • Glutamate receptors • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P2X receptors

  9. CSB Fig 3:11 Nicotinic acetylcholine receptor Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  10. ROCs • Cysteine-loop receptors • Nicotinic acetylcholine receptors (nAChRs) • 5-Hydroxytryptamine 3 (5-HT3) receptors • γ-Aminobutyric acid (GABA) receptors • Glycine receptors (GlyRs) • Glutamate receptor • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P2X receptors

  11. CSB Fig 3:13 Ionotropic glutamate receptor Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  12. CSB Fig 3:14 AMPA receptor phosphorylation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  13. CSB Fig 3:15 NMDA receptor Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  14. ROCs • Cysteine-loop receptors • Nicotinic acetylcholine receptors (nAChRs) • 5-Hydroxytryptamine 3 (5-HT3) receptors • γ-Aminobutyric acid (GABA) receptors • Glycine receptors (GlyRs) • Glutamate receptors • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P2X receptors

  15. CSB Fig 3:16 P2X receptor structure Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  16. CSB Fig 3:10 Ca2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  17. CSB Fig 3: Cyclic nucleotide-gated channels Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  18. CSB Fig 3:10 Ca2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  19. CSB Fig 3:07 CaV2 channel family Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  20. CSB Fig 3:10 Ca2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  21. CSB Fig 3:19 Conformational coupling hypothesis Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  22. CSB Fig 3:22 STIM-induced Ca2+ entry Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  23. CSB Fig 3:46 Ryanodinereceptor structure Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  24. CSB Fig 3:47 InsP3R regulation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  25. CSB Fig 2:19 Ca2+-induced Ca2+ release Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  26. CSB Fig 2:20 Ca2+ transient mechanisms Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  27. CSB Fig 2:21 Temporal aspects Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

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