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06-1536

06-1536. Shelley J Newman DVM, DVSc, DACVP M. Souza, C. Greenacre, G. Daniels. Signalment. Female,10 year old Yellow-naped Amazon parrot. History. 10 day history of anemia, lymphocytic leukocytosis and lethargy. Physical exam. No abnormalities noted initially. Serial Chemistry Results.

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06-1536

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  1. 06-1536 Shelley J Newman DVM, DVSc, DACVP M. Souza, C. Greenacre, G. Daniels

  2. Signalment Female,10 year old Yellow-naped Amazon parrot

  3. History 10 day history of anemia, lymphocytic leukocytosis and lethargy

  4. Physical exam No abnormalitiesnoted initially

  5. Serial Chemistry Results • Hypoproteinemia • Hypoalbuminemia • Hypophosphatemia • Hypocholesterolemia • Monoclonal gammopathy (Beta region)

  6. Diagnostic Work up Imaging • Contrast radiography • Contrast CT • PETscan

  7. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  8. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  9. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  10. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  11. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  12. Histopathology • Expansion and infiltration • Round cell population • Abundant cytoplasm • Round vesicular nuclei • Prominent multiple nucleoli • Rare mitoses • Anisokaryosis and anisocytosis • Little intra-epithelial involvement

  13. Special Stains • ZN and Fites acid fast stains were negative • Considered cell size and plasmacytoid differentiation as indication of plasma cell tumor or lymphosarcoma • Recommended immunohistochemistry

  14. Monoclonal CD3 Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  15. Monoclonal CD3 Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  16. IMHC Results • CD79 did not produce staining in the avian splenic control or the intestinal infiltrate • BLA.36 did not produce staining in the avian splenic control • CD3 polyclonal and CD3 monoclonal stained splenic control tissue and the neoplastic cells

  17. Diffuse Intestinal T cell Lymphosarcoma

  18. Outcome • Owner elected euthanasia after seven weeks of chemotherapy

  19. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  20. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  21. Discussion • LSA is rare in birds but typically presents as cutaneous or peri-orbital lesions • Not thought to be virally induced in psittacines

  22. Discussion • No previous reports of diffuse T cell intestinal lymphosarcoma in psittacines • Prognosis is poor despite chemotherapy as with the T cell immunophenotype in mammals. • Unique findings in this case included gammopathy and lymphocytic leukosis

  23. Monoclonal Gammopathy (Beta) • Might have more strongly supported B cell origin • Been reported twice before with psittacine T cell lymphosarcoma • Unlikely to result from unidentified infectious etiology

  24. References • Ramos-Vara JA, Smith EJ, Watson GL. Lymphosarcoma with plasmacytoid differentiation in a Scarlet macaw.Avian Dis 1997, 41: 499-504. • de Wit M, Schoemaker NJ, Kik MJL, Westerhof I. Hypercalcemia in two amazon parrots with malignant lymphoma.Avian Dis 2003, 47:223-228.

  25. Acknowledgements • Dale Godson – Prairie Diagnostics • Histopathology Laboratory - UT • Ladonna Mrkonjich • Dr. Donnell • Dr. Roslyn Casimir

  26. Questions??

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