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Microfluidic-Directed Self-Assembly of Lipids into Nanoliposomes

MIT. enterprise forum of washington - baltimore. Microfluidic-Directed Self-Assembly of Lipids into Nanoliposomes. Wyatt N. Vreeland, PhD National Institute of Standards & Technology Gaithersburg, MD, USA. MIT. enterprise forum of washington - baltimore. Technology Summary.

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Microfluidic-Directed Self-Assembly of Lipids into Nanoliposomes

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  1. MIT enterprise forum of washington-baltimore Microfluidic-Directed Self-Assembly of Lipids into Nanoliposomes Wyatt N. Vreeland, PhD National Institute of Standards & Technology Gaithersburg, MD, USA www.mitef.org

  2. MIT enterprise forum of washington-baltimore Technology Summary • Automated and reproducible production of high quality liposomes • A microfluidic device capable of producing liposomes when feed a lipid solution • Liposomes are nano-scale containers made from lipids www.mitef.org

  3. MIT enterprise forum of washington-baltimore Technology Description • How it works: • Three streams, 2 water and 1 alcohol mix in a controlled and reproducible way • Makes liposomes in one step without the need for post processing www.mitef.org

  4. MIT enterprise forum of washington-baltimore Technology Description • How it works: • Three streams, 2 water and 1 alcohol mix in a controlled and reproducible way • Makes liposomes in one step without the need for post processing www.mitef.org

  5. MIT enterprise forum of washington-baltimore Applications • Drug delivery • Drug flavorings • Cosmetics • Controlled drug release • Pharmaceutical and value-added drugs www.mitef.org

  6. MIT enterprise forum of washington-baltimore The Market • Many FDA-approved drugs based on liposomes: Anti-Fungal Ovarian and Breast Cancers Anti-Cancer • MyocetTM (Liposome encapsulated doxorubicin citrate complex) • Approved in the EU www.mitef.org

  7. MIT enterprise forum of washington-baltimore Current Status • Currently only laboratory scale device • Challenge to scale-up: mg –> gm • Intellectual property • Patent filed and under review • Product ripe for commercialization • Trends: Increasing interest from pharma in liposome implementation www.mitef.org

  8. MIT enterprise forum of washington-baltimore Next Steps • Needs to be scaled up • Needs to be engineered from a prototype to a working product • Technology is developed and robust at laboratory scales www.mitef.org

  9. MIT enterprise forum of washington-baltimore Contact • For more information: • Wyatt N. Vreeland, PhD • National Institute of Standards & Technology • 1 (301) 975-8513 (voice) • 1 (301) 975-4845 (fax) • wyatt.vreeland@nist.gov www.mitef.org

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