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Nanometer Resolution Imaging and Computational Analysis of Axonal Transport Defects in Drosophila Models of Alzheimer’s Disease. Minhua Qiu Department of Biomedical Engineering Advisor: Dr. Ge Yang. Analysis of Axonal Transport Defects in Fly Models of AD. Nanometer Resolution Detection.
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Nanometer Resolution Imaging and Computational Analysis of Axonal Transport Defects in Drosophila Models of Alzheimer’s Disease MinhuaQiu Department of Biomedical Engineering Advisor: Dr. Ge Yang • Analysis of Axonal Transport Defects in Fly Models of AD • Nanometer Resolution Detection Fluorescence Imaging Multi-peak Fitting Brain Segmental Nerves Nanometer Resolution Detection • System Verification Fluorescent beads Trajectory Recovery APP-YFP vesicle imaged A typical Fluorescence Image taken by Nikon Eclipse TE2000-U inverted microscope with a 100×/1.40 NA oil objective Pattern Recognition Nanometer Resolution Piezo Stage Library of Transport Defects Distance: 88 µm Operated by Labview 16 nm Nikon Eclipse TE2000-U inverted microscope 8 nm 0 nm 0 2 4 6 secs