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Daily fMRI Practice

Daily fMRI Practice. John Li MD 10/7/2010. When you first design a fMRI study, you need to. Understand the fMRI requirements. Design and choose proper paradigms. Choose the right coil, right gradient and sequences to acquire fMRI data. Choose proper methods to minimize motion.

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Daily fMRI Practice

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  1. Daily fMRI Practice John Li MD 10/7/2010

  2. When you first design a fMRI study, you need to • Understand the fMRI requirements. • Design and choose proper paradigms. • Choose the right coil, right gradient and sequences to acquire fMRI data. • Choose proper methods to minimize motion.

  3. Daily fMRI Practice Mainly Involve Follow Modules Experiment Design Paradigm Result Interpretation Post Processing Data Acquisition

  4. Designs for fMRI Data Acquisition • Block Design • Event Related Design • Resting State

  5. Paradigms • Good Design • Careful Selection • Proper Delivery

  6. Good Paradigm Performance Needs • Good instruction, correct understanding of paradigm, good performance of paradigm. • Close observation of subject performing paradigm. • Properly reminding the subjects about the coming steps

  7. Example:Multi-surface Wooden Ball and Multi-grades Sand Paper Stimulus and Design

  8. Example Results • Gao JH, Parsons LM, Bower JM, Xiong JH, Li JQ, Fox PT (1996): Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272:545-547

  9. Checkerboard is one Well-Known ParadigmVisual Stimulus Block Design

  10. Different Frequency Will Stimulate Visual Cortex Differently

  11. The Visual Cortex Activation Area will be Different with Different Designs of CheckerboardsTargeting Different Parts of Visual Field Full Visual Field

  12. Flashing Light and Tactile Stimulator Off On Vibration

  13. Comparison of Different Pulse Sequences Used in fMRI TSE Segmented EPI Conventional GRE Single Shot EPI

  14. Baboon’s Visual and Motor Activation Results • Thanks to Wey, Hsiao-Ying Monica for the picture.

  15. Human Bimanual Finger Tapping Sequence fMRI Result Thanks to Crystal Franklin for the picture.

  16. Psychological Paradigms N-back, Gambling, Shape-Matching, Face-Matching, Stroop…

  17. Coil Selection • Any coil can be used in fMRI studies. When using GRAPPA or mSENSE, phased array coils are required. 12 Channel Phased Array Coil T/R Head Coil

  18. With Insert Gradient, High Resolution fMRI Will be Possible

  19. Reducing Motion is One of the Keys for a Successful fMRI

  20. Reducing Motion is One of the Keys to fMRI Success

  21. Reducing Motion is One of the Keys to fMRI Success

  22. Reducing Motion is One of the Keys to fMRI Success Baboon Head Holder

  23. Adjusting Scan Parameters • TR, TE & flip angle (why) • Field of view, resolution & matrix size (trade off) • Slice thickness & gap between slices • Number of slices & slice acquisition order • Receiver bandwidth & echo train space

  24. Activation pattern in ASL with 2x2x5 300ml Water 300ml TRUTOL 75 (Glucose Tolerance Beverage) Thanks Claudia Huerta for Data Analysis

  25. Motion artifact shares similar activation pattern Hypothalamus Motion related areas

  26. Slice Positioning

  27. GRAPPA and mSENSE • When you choose parallel imaging technique GRAPPA or mSENSE, you can get more slices for a given TR.

  28. Auto Generation of fMRI Results

  29. Interpretation of fMRI Results Hypothalamus shows decreased activation after glucose ingestion.

  30. Supplementing MRA with fMRI MR Angiography Demonstrates an AVM (Arteriovenous Malformation) Yellow Arrow: Supply Artery Blue Arrow: AVM Red Arrow: Drain Vein

  31. Interpretation of fMRI Results AVM T1 Axial Images T2 Axial Images

  32. Interpretation of fMRI Results Verb Generation from Noun • Thank to Crystal Franklin for the pictures. Language Center Is Dominant in the Left Hemisphere Verb Generation from Picture

  33. Thanks!

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