30 likes | 176 Views
Thymidylate synthetase. Folate (F). DNA. NADPH + H +. Dihydrofolate (FH 2 ). Methionine. dTMP. ATP. Methionine adenosyltransferase. NADPH + H +. PPi + Pi. S-Adenosylmethionine. Tetrahydrofolate (FH 4 ). Serine. Acceptor. Methyl transferase. Methylated acceptor. Glycine. dUMP.
E N D
Thymidylate synthetase Folate (F) DNA NADPH + H+ Dihydrofolate (FH2) Methionine dTMP ATP Methionine adenosyltransferase NADPH + H+ PPi + Pi S-Adenosylmethionine Tetrahydrofolate (FH4) Serine Acceptor Methyl transferase Methylated acceptor Glycine dUMP Methionine synthase, MSR and vitamin B12 5,10-Methylene FH4 S-Adenosylhomocysteine MTHFR Adenosine 5-Methyl FH4 Homocysteine Serine Cystathionine b-synthase Cystathionine Cystathionase Cysteine + NH3 + a-Ketobutyrate