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Central Dogma, Expanded!

Central Dogma, Expanded!. Sept. 16, 2004. Chapters 13, 14 & 15 for details. RNA transcript. DNA. mRNA. Polypeptides. change of scale. change of scale. + extra cellular factors. Central Dogma plus …. System Effects. Cartoon of Central Dogma. Eukaryotes. Chromosome uncoiling

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Central Dogma, Expanded!

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  1. Central Dogma, Expanded! Sept. 16, 2004 Chapters 13, 14 & 15 for details

  2. RNA transcript DNA mRNA Polypeptides change of scale change of scale + extra cellular factors Central Dogma plus … System Effects

  3. Cartoon of Central Dogma

  4. Eukaryotes • Chromosome uncoiling • DNA promoter identified and activated • RNA polymerase introduced • RNA synthesis (primary transcript, hnRNA) • 5’ Cap added • poly-A tail added • Splicing of introns, linking exons • Transport to cytoplasm • Initial ribosome binding – mAUG – • Completion of ribosome and second codon • Synthesis of polypeptide • Post translational modification/transport to functional form and place

  5. Nuclear RNA Processing - origin

  6. Nuclear RNA Transcription - end

  7. “Exon Choice” RNA Transcript Processing

  8. Intron Removal Note: different snRNAs connect different places in splicing – including across exons – so exons may be excised along with introns (“exon choice”) MultiplesnRNPs

  9. Translation to ER

  10. Regulatory RNAs (introns +?) siRNA “silencing RNA” iRNA “interference RNA” ???? Types of RNA in Eukaryote

  11. Flies and Mice Each Region has differentpatterns of gene regulation!

  12. Developmental Patterns in Plants 23-44

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