1 / 1

Polymyositis and Dermatomyositis Bohan and Peter, N Engl J Med 1975, 292:344

Polymyositis and Dermatomyositis Bohan and Peter, N Engl J Med 1975, 292:344. Symmetrical weakness of the limb girdle muscles and anterior neck flexors, progressing over weeks to months, with or without dysphagia or respiratory muscle involvement

vivi
Download Presentation

Polymyositis and Dermatomyositis Bohan and Peter, N Engl J Med 1975, 292:344

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Polymyositis and DermatomyositisBohan and Peter, N Engl J Med 1975, 292:344 • Symmetrical weakness of the limb girdle muscles and anterior neck flexors, progressing over weeks to months, with or without dysphagia or respiratory muscle involvement • Muscle biopsy evidence of necrosis of myofibers, phagocytosis, regeneration with basophils, large vesicular sarcolemmal nuclei, and prominent nucleoli, atrophy in a perifascicular distribution, variation in fiber size and an inflammatory exudate, often perivascular • Elevation in serum of skeletal-muscle enzymes, particularly the CK and often aldolase, aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT or SGPT) and lactate dehydrogenase (LDH) • Electromyographic triad of short, small, polyphasic motor units, fibrillations, positive sharp waves and insertional irritability, and bizarre, high frequency repetitive discharges • Any one of the characteristic dermatologic features of the rash of DM

More Related