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BAL ABNORMALITIES AND RESPIRATORY SYMPTOMS IN MOLYBDENUM EXPOSED HARD-METAL WORKERS

BAL ABNORMALITIES AND RESPIRATORY SYMPTOMS IN MOLYBDENUM EXPOSED HARD-METAL WORKERS Harald C Ott, Christian Prior, Manfred Herold, Markus Riha, Guenter Ott Department of Cardiac Surgery, Department of Medicine, University Hospital Innsbruck. INTRODUCTION:

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BAL ABNORMALITIES AND RESPIRATORY SYMPTOMS IN MOLYBDENUM EXPOSED HARD-METAL WORKERS

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  1. BAL ABNORMALITIES AND RESPIRATORY SYMPTOMS IN MOLYBDENUM EXPOSED HARD-METAL WORKERS Harald C Ott, Christian Prior, Manfred Herold, Markus Riha, Guenter Ott Department of Cardiac Surgery, Department of Medicine, University Hospital Innsbruck INTRODUCTION: A group of hard-metal dust exposed workers suffer from cough and chest thightness without any signs of respiratory disease found in common occupational screening programs. The aim of the study was to detect an early adverse effect of chronic inhalative molybdenum and hard-metal dust exposure in those workers. RESULTS: Fig.1 to 6.: Results of the lung function tests and the BAL cytology in symptomatic and non symptomatic workers and in the control group. A higher percentage count of macrophages correlated with a decrease of carbon monoxyde transfer coefficient (KCO) (r=0,58, p<0,01) None of the investigated individuals showed firm radiological signs of interstitial lung disease p<0,05 p<0,05 p<0,05 p<0,05 PATIENTS: 43 employees of a hard metal plant, chronically exposed to hard-metal and molybdenum dusts and 23 healthy individuals without inhalative exposure were examined. Among the workers, 33 were suffering from cough and chest thightness whereas 10 were not symptomatic. CONCLUSION: Chronic hard-metal and molybdenum dust exposure causes respiratory symptoms and a relative increase in inflammatory BAL cells in a subgroup of employees with no functional and radiological signs of respiratory disease. The cellular patterns we found in BAL in the group of symptomatic workers are similar to those found in patients suffering from interstitial lung disease, but of a more moderate extent. Respiratory symptoms in „healthy“ workers are related to a change of BAL cellular patterns and therefore have to be considered as an indicator for an early adverse effect. p<0,05 p<0,01 p<0,001 p<0,001 • METHODS: • Chest X-rays were seen by two independent pulmologists. Spirometry was performed on a Jaeger spirometer. Bronchoalveolar Lavage cells were spun into slices and stained May-Gruenwald-Giemsa • Inhalative exposure was confirmed by electron mycroscopy of BAL fluid. (left top corner) p<0,05 p<0,001 p<0,05 Corresponding author: Harald C Ott MD, Department of Cardiac Surgery, University Hospital Innsbruck, Anichstraße , 6020 Innsbruck, AUSTRIA, Fax: 00435125042528, Phone: 00435125043806, e-mail: h.c.ott@aon.at

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